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SUV420H1 Recombinant Protein

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS515679

Description: Recombinant full-length human SUV420H1 (KMT5B) was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag.Scientific Background: Histone-lysine N-methyltransferase, Suppressor of variegation 4-20 homolog 1 SUV420H1 specifically… More details

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Product Overview

Online Datasheet in PDF
Product Name
SUV420H1, Recombinant Protein
Full Product Name
SUV420H1 (KMT5B), Active
Product Gene Name
SUV420H1 recombinant protein
Product Synonym Gene Name
KMT5B; CGI-85; MGC21161; MGC703
Host
Sf9 insect cells using baculovirus
Form/Format
50mM Tris-HCl, pH 7.5, 150mM NaCl, 10mM glutathione, 0.1mM EDTA, 0.25mM DTT, 0.1mM PMSF, 25% glycerol.
Preparation and Storage
Store product at -70 degree C.
For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature.
For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
Molecular Weight
160 kDa
Sequence Positions
Full length
OMIM
AP002992 Genomic DNA
Species
Human
Tag
GST tag
Dry Ice Shipment
Extra charge fee may add to your shipping cost as dry ice is required to ship this product.

Product Categories/Family for SUV420H1 recombinant protein

Enzymes; Active Methyltransferases
Applications Tested/Suitable for SUV420H1 recombinant protein
Methyltransferase Assay

Testing Data of SUV420H1 recombinant protein

SUV420H1 Recombinant Protein – Cat# MBS515679

Testing Data #2 of SUV420H1 recombinant protein

SUV420H1 Recombinant Protein, Testing Data #2 – Cat# MBS515679

Product References and Citations for SUV420H1 recombinant protein

1. Tryndyak VP, et al: Loss of DNA methylation and histone H4 lysine 20 trimethylation in human breast cancer cells is associated with aberrant expression of DNA methyl-transferase 1, Suv4-20h2 histone methyltransferase and methyl-binding proteins. Cancer Biol Ther. 5 (1):65-70, 2006. 2. Lai CH, et al: Identification of novel human genes evolutionarily conserved in Caenorhabditis elegans by comparative proteomics. Genome Res. 10 (5):703-13, 2000.

Other Notes

Small volumes of SUV420H1 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for SUV420H1 purchase

MBS515679 is a recombinant protein targeting SUV420H1. Also known as SUV420H1 (KMT5B), Active. Host: Sf9 insect cells using baculovirus.

Additional Details

NCBI/Uniprot data below describe general gene information for SUV420H1. It may not necessarily be applicable to this product.

NCBI GI #
73695393
NCBI GeneID
51111
NCBI Accession #
BC103498
UniProt Secondary Accession #
Q3SX56; Q4V775; Q6P150; Q96E44; Q9BUL0; Q9H022; Q9H2K3; Q9NXV3; Q9Y393; B7WNX7
UniProt Related Accession #
Q4FZB7
NCBI Official Full Name
Homo sapiens suppressor of variegation 4-20 homolog 1 (Drosophila), transcript variant 1, mRNA
NCBI Official Synonym Full Names
lysine methyltransferase 5B
NCBI Official Symbol
KMT5B
NCBI Official Synonym Symbols
CGI85; CGI-85; SUV420H1
UniProt Protein Name
Histone-lysine N-methyltransferase KMT5B
UniProt Synonym Protein Names
Lysine N-methyltransferase 5B; Lysine-specific methyltransferase 5B
UniProt Gene Name
KMT5B
UniProt Synonym Gene Names
Su(var)4-20 homolog 1; Suv4-20h1
NCBI Protein Information
histone-lysine N-methyltransferase KMT5B

NCBI Summary for SUV420H1

This gene encodes a protein that contains a SET domain. SET domains appear to be protein-protein interaction domains that mediate interactions with a family of proteins that display similarity with dual-specificity phosphatases (dsPTPases). The function of this gene has not been determined. Several alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2014]
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UniProt Comments for SUV420H1

SUV420H1: a protein methyltransferase that specifically trimethylates 'Lys-20' of histone H4. H4 'Lys-20' trimethylation represents a specific tag for epigenetic transcriptional repression. Mainly functions in pericentric heterochromatin regions, thereby playing a central role in the establishment of constitutive heterochromatin in these regions. SUV420H1 is targeted to histone H3 via its interaction with RB1 family proteins (RB1, RBL1 and RBL2). Strongly down-regulated in breast cancer cells. Belongs to the histone-lysine methyltransferase family. Suvar4-20 subfamily. Three alternatively-spliced isoforms have been described.

Protein type: Amino Acid Metabolism - lysine degradation; EC 2.1.1.43; Methyltransferase; Methyltransferase, protein lysine

Chromosomal Location of Human Ortholog: 11q13.2

Cellular Component: nucleoplasm; nucleus

Molecular Function: histone-lysine N-methyltransferase activity
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Research Articles on SUV420H1

1. overexpression of SUV420H1 may result in activation of the ERK signaling pathway

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Pathways associated with SUV420H1 recombinant protein

 Products by Pathway  Pathway Diagram
 Glucocorticoid Receptor Regulatory Network Pathway antibodies  Glucocorticoid Receptor Regulatory Network Pathway Diagram
 Lysine Degradation Pathway antibodies  Lysine Degradation Pathway Diagram
 Lysine Degradation Pathway antibodies  Lysine Degradation Pathway Diagram

Diseases associated with SUV420H1 recombinant protein

 Disease Name  Pubmed Publications
 Neoplasms Antibodies  >1 publications with SUV420H1 and Neoplasms

Organs/Tissues associated with SUV420H1 recombinant protein

 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >1 publications with SUV420H1 and Blood
 Muscle Antibodies  >1 publications with SUV420H1 and Muscle
 Brain Antibodies  >1 publications with SUV420H1 and Brain
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