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NDR2 Recombinant Protein

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS515691

Description: Recombinant full-length human NDR2 (STK38L) was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag.Scientific Background: NDR2 or Nuclear Dbf2-related protein is a serine/threonine kinase in the subgroup of the AGC kinase… More details

$445 / 0.01 mg +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
NDR2, Recombinant Protein
Full Product Name
NDR2, Active
Product Gene Name
NDR2 recombinant protein
Product Synonym Gene Name
KIAA0965; STK38L
Host
Sf9 insect cells using baculovirus
Form/Format
50mM Tris-HCl, pH 7.5, 150mM NaCl, 10mM glutathione, 0.1mM EDTA, 0.25mM DTT, 0.1mM PMSF, 25% glycerol.
Preparation and Storage
Store product at -70 degree C.
For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature.
For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
Molecular Weight
~82 kDa
Sequence Positions
Full Length
OMIM
AB023182 mRNA
3D Structure
ModBase 3D Structure for Q9Y2H1
Species
Human
Tag
GST tag
Dry Ice Shipment
Extra charge fee may add to your shipping cost as dry ice is required to ship this product.

Product Categories/Family for NDR2 recombinant protein

Enzymes; Active Kinases
Applications Tested/Suitable for NDR2 recombinant protein
Kinase Assay, Western Blot (WB)

Testing Data of NDR2 recombinant protein

NDR2 Recombinant Protein – Cat# MBS515691

Testing Data #2 of NDR2 recombinant protein

NDR2 Recombinant Protein, Testing Data #2 – Cat# MBS515691

Product References and Citations for NDR2 recombinant protein

1. Millward, T. et.al: Molecular cloning and characterization of a conserved nuclear serine (threonine) protein kinase. Proc. Nat. Acad. Sci. 92: 5022-5026, 1995. 2. Vichalkovski A. et.al: NDR kinase is activated by RASSF1A/MST1 in response to Fas receptor stimulation and promotes apoptosis. Curr Biol. 2008 Dec 9;18 (23):1889-95. 3. Devroe E. et.al: Human Mob proteins regulate the NDR1 and NDR2 serine-threonine kinases. J. Biol. Chem. 279:24444-24451, 2004.

Other Notes

Small volumes of NDR2 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for NDR2 purchase

MBS515691 is a recombinant protein targeting NDR2. Also known as NDR2, Active. Host: Sf9 insect cells using baculovirus.

Additional Details

NCBI/Uniprot data below describe general gene information for NDR2. It may not necessarily be applicable to this product.

NCBI GI #
209571510
NCBI GeneID
23012
NCBI Accession #
NM_015000.3
UniProt Primary Accession #
Q9Y2H1
UniProt Secondary Accession #
Q8TBX7; A8K4U0; B4E3J8
UniProt Related Accession #
Q9Y2H1
GenBank Nucleotide #
NM_015000
NCBI Official Full Name
Homo sapiens serine/threonine kinase 38 like (STK38L), mRNA
NCBI Official Synonym Full Names
serine/threonine kinase 38 like
NCBI Official Symbol
STK38L
NCBI Official Synonym Symbols
NDR2
UniProt Protein Name
Serine/threonine-protein kinase 38-like
UniProt Synonym Protein Names
NDR2 protein kinase; Nuclear Dbf2-related kinase 2
Protein Family
Serine/threonine-protein kinase
UniProt Gene Name
STK38L
NCBI Protein Information
serine/threonine-protein kinase 38-like

UniProt Comments for NDR2

NDR2: a non-receptor S/T kinase of the AGC group. Activated by binding of S100B which releases autoinhibitory N-lobe interactions, enabling ATP to bind followed by autophosphorylation of a serine in the kinase domain. A threonine in the C-terminal domain then undergoes calcium-dependent phosphorylation by an upstream kinase. Interactions between the phosphorylated threonine and the N-lobe promote additional structural changes that complete the activation of the kinase. Autoinhibition is also released by the binding of MOB1/MOBKL1A and MOB2/HCCA2 to the N-terminal of STK38L. May be involved in the regulation of structural processes in neuronal cells.

Protein type: AGC group; EC 2.7.11.1; Kinase, protein; NDR family; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor)

Chromosomal Location of Human Ortholog: 12p11.23

Cellular Component: actin cytoskeleton; cytoplasm; cytosol

Molecular Function: ATP binding; magnesium ion binding; protein binding; protein serine/threonine kinase activity

Biological Process: peptidyl-serine phosphorylation; protein amino acid phosphorylation; regulation of cellular component organization and biogenesis
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Research Articles on NDR2

1. cyclin D1 has a role in promoting cell cycle progression by enhancing NDR1/2 kinase activity independent of Cdk4

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with NDR2 recombinant protein

 Reference Product  PubMed Publications
 S100B recombinant protein  >2 publications with NDR2 and S100B
 HCCA2 recombinant protein  >1 publications with NDR2 and HCCA2
 STK24 recombinant protein  >1 publications with NDR2 and STK24

Diseases associated with NDR2 recombinant protein

 Disease Name  Pubmed Publications
 Atrophy Antibodies  >1 publications with NDR2 and Atrophy
 Nervous System Diseases Antibodies  >1 publications with NDR2 and Nervous System Diseases
 Liver Diseases Antibodies  >1 publications with NDR2 and Liver Diseases
 Adenocarcinoma Antibodies  >1 publications with NDR2 and Adenocarcinoma
 Liver Neoplasms Antibodies  >1 publications with NDR2 and Liver Neoplasms
 Breast Neoplasms Antibodies  >1 publications with NDR2 and Breast Neoplasms
 Carcinoma, Hepatocellular Antibodies  >1 publications with NDR2 and Carcinoma, Hepatocellular
 Necrosis Antibodies  >1 publications with NDR2 and Necrosis

Organs/Tissues associated with NDR2 recombinant protein

 Organ/Tissue Name  Pubmed Publications
 Eye Antibodies  >3 publications with NDR2 and Eye
 Nerve Antibodies  >2 publications with NDR2 and Nerve
 Blood Antibodies  >2 publications with NDR2 and Blood
 Skin Antibodies  >1 publications with NDR2 and Skin
 Heart Antibodies  >1 publications with NDR2 and Heart
 Muscle Antibodies  >1 publications with NDR2 and Muscle
 Liver Antibodies  >1 publications with NDR2 and Liver
 Brain Antibodies  >1 publications with NDR2 and Brain
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