UBA7 Recombinant Protein

Description: Recombinant full-length human UBA7 (UBE1L) was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag.
Scientific Background: UBA7 or or ubiquitin-like modifier activating enzyme 7 is a member of the E1 ubiquitin-activating enzyme family which is a retinoid target that triggers promyelocytic leukemia (PML)/retinoic acid receptor alpha (RARalpha) degradation and apoptosis in acute promyelocytic leukemia, where it is involved in the conjugation of the ubiquitin-like interferon-stimulated gene 15 protein. UBA7 is expressed in a variety of tissues, including normal lung, but highly expressed in a large series of lung cancer cell lines (1). UBA7 may represent a second, autosomal member of the ubiquitin-activating gene family, which play a role in the ubiquitin conjugation pathway, which is of central importance in all eukaryotes (2).

1. Carritt, B.et.al: A gene from human chromosome region 3p21 with reduced expression in small cell lung cancer. Cancer Res. 52: 1536-1541, 1992. 2. Kok, K.et.al: A gene in the chromosomal region 3p21 with greatly reduced expression in lung cancer is similar to the gene for ubiquitin-activating enzyme. Proc. Nat. Acad. Sci. 90: 6071-6075, 1993.

Small volumes of UBA7 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

MBS515705 is a recombinant protein targeting UBA7. Also known as UBA7 (UBE1L) Protein. Host: Sf9 insect cells using baculovirus.