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CD226 Antibody – Rat Monoclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS520071

CD226 (also called DNAM-1) is constituitively expressed on naive CD8+ T cells, as well as subsets of naïve CD11b+ macrophages and NK cells. It is also found on a lower percentage (~40%) of unactivated CD4+ T cells. CD226 is functional upon T cell activation,… More details

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Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Product Name
CD226, Monoclonal Antibody
Full Product Name
Anti-Mouse CD226, Purified, (clone: 15F.10E5), (rat IgMk)
Product Gene Name
Product Synonym Names
CD226, Purified, (clone: 15F.10E5), (rat IgMk); Purified Anti-Mouse CD226 (DNAM-1) Monoclonal Antibody
Clonality
Monoclonal
Isotype
Rat IgMkappa
Clone Number
15F.10E5
Host
Rat
Species Reactivity
Mouse
Form/Format
Purified (Purified Ig buffered in PBS and 0.02% NaN3 (purified from ascitic fluid via Protein G Chromatography).)
Concentration
Antibody Concentration: 0.1 mg/ml (lot specific)
Specificity
CD226 (Mouse CD226 (DNAM-1))
Preparation and Storage
Store at 4 degree C. For long term storage, aliquot and freeze unused portion at -20 degree C in volumes appropriate for single usage. Avoid freeze/thaw cycles
Molecular Weight
38,614 Da
Chromosome Location
Chromosome: 18; NC_000018.9 (67530192..67624412, complement). Location: 18q22.3
OMIM
605397
3D Structure
ModBase 3D Structure for Q15762
Immunogen
AE7 cells
Donor
Lewis rat
Fusion Partner
SP 2/0 myeloma
Presentation
250 ug purified Ig buffered in PBS and 0.02% NaN3
Applications Tested/Suitable for anti-CD226 antibody
Immunohistochemistry (IHC)

Testing Data of anti-CD226 antibody

Rat Anti-CD226 Monoclonal Antibody – Cat# MBS520071

Other Notes

Small volumes of anti-CD226 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for CD226 purchase

MBS520071 is an antibody targeting CD226. Also known as Anti-Mouse CD226, Purified, (clone: 15F.10E5), (rat IgMk). Reactive in Mouse. Host: Rat.

Additional Details

NCBI/Uniprot data below describe general gene information for CD226. It may not necessarily be applicable to this product.

NCBI GI #
NCBI GeneID
NCBI Accession #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
GenBank Nucleotide #
NCBI Official Full Name
CD226 antigen
NCBI Official Synonym Full Names
CD226 molecule
NCBI Official Symbol
CD226
NCBI Official Synonym Symbols
PTA1; DNAM1; DNAM-1; TLiSA1
UniProt Protein Name
CD226 antigen
UniProt Synonym Protein Names
DNAX accessory molecule 1
Protein Family
UniProt Gene Name
CD226
UniProt Synonym Gene Names
DNAM1; DNAM-1
UniProt Entry Name
CD226_HUMAN
NCBI Protein Information
CD226 antigen; adhesion glycoprotein; DNAX accessory molecule 1; DNAX accessory molecule-1; platelet and T cell activation antigen 1; T lineage-specific activation antigen 1 antigen

NCBI Summary for CD226

This gene encodes a glycoprotein expressed on the surface of NK cells, platelets, monocytes and a subset of T cells. It is a member of the Ig-superfamily containing 2 Ig-like domains of the V-set. The protein mediates cellular adhesion of platelets and megakaryocytic cells to vascular endothelial cells. The protein also plays a role in megakaryocytic cell maturation. [provided by RefSeq, Jul 2008]
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UniProt Comments for CD226

Function: Receptor involved in intercellular adhesion, lymphocyte signaling, cytotoxicity and lymphokine secretion mediated by cytotoxic T-lymphocyte (CTL) and NK cell. Ref.1

Subunit structure: Interacts with PVR and PVRL2. Ref.7 Ref.8

Subcellular location: Membrane; Single-pass type I membrane protein

Potential.

Tissue specificity: Expressed by peripheral blood T-lymphocytes. Ref.1

Sequence similarities: Contains 2 Ig-like C2-type (immunoglobulin-like) domains.
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Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

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