CD45RC Antibody – Mouse Monoclonal

Rat Leukocyte Common Antigen has been shown to exist in different forms on different lymphoid cell types. Rat L-CA on thymocytes gives one main band at 180 kDa, T cells show 4 bands at 180, 190, 200 and 220 kDa and B cells; one broad band at 240 kDa. T helper and T cytotoxic cell subsets show the same 4 bands with some differences in the proportions of each. MBS520166 reacts with the high molecular weight form of the leukocyte common antigen (2) which includes the 240 kDa form on B cells as well as a subfraction of the 190, 200 and 220 kDa forms, but not with the 180 kDa form of T cells or thymocytes. (5) Thus, MBS520166 reacts with B cells, cytotoxic T cells and helper cells for T cell responses but not with thymocytes or helper T cells for in vivo antibody responses. (5) Consequently, this antibody can be used to identify B cells, all CD8+ve T cells, 75% CD4+ve T cells and 50% bone marrow cells. This, antibody also divides rat CD4+ve T cells into two phenotypically distinct populations differing in their helper activities (6,7).

Small volumes of anti-CD45RC antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

MBS520166 is an antibody targeting CD45RC. Also known as Anti-Rat CD45RC Purified (Clone OX-22) (mouse IgG1). Reactive in Rat. Host: Mouse.