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CD94 Antibody – Rat Monoclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS520254

anti-mouse CD94 monoclonal antibody detects the mouse CD94 receptor. This 180 amino acid, 70 KDa transmembrane glycoprotein belongs to a family of murine Natural Killer (NK) cell receptors for MHC class I and is co-expressed as a heterodimer with NKG2 on the… More details

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Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Product Overview

Product Name
CD94, Monoclonal Antibody
Full Product Name
Anti-Mouse CD94, PE, (clone: 15F.18D1), (rat IgG1k)
Product Gene Name
anti-CD94 antibody
Product Synonym Names
CD94, PE, (clone: 15F.18D1), (rat IgG1k); Anti-Mouse CD94 Monoclonal Antibody
Clonality
Monoclonal
Isotype
Lewis Rat IgG1kappa
Clone Number
15F.18D1
Host
Rat
Species Reactivity
Mouse
Form/Format
PE
Concentration
0.1 mg/ml (lot specific)
Specificity
CD94 (Mouse CD94 transmembrane glycoprotein)
Preparation and Storage
For all formats, store at 4 degree C. DO NOT FREEZE PE conjugates. For long term storage (Purified, Biotin, FITC, No Azide), aliquot and freeze unused portion at -20 degree C in volumes appropriate for single usage. Avoid freeze/thaw cycles.
Molecular Weight
20,513 Da
Chromosome Location
Chromosome: 12; NC_000012.11 (10457050..10469850). Location: 12p13
OMIM
602894
3D Structure
ModBase 3D Structure for Q13241
Immunogen
Murine T cell clone AE7 cells
Donor
Lewis Rat spleen cells
Fusion Partner
Murine myeloma cell line SP2/0
Presentation
Biotin/FITC/PE conjugated IgG buffered in PBS, 0.02% NaN3 and EIA grade BSA as a stabilizing protein to bring total protein concentration to 4-5 mg/mL.
Applications Tested/Suitable for anti-CD94 antibody
Immunohistochemistry (IHC), ELISA (EIA), Immunofluorescence (IF)

Testing Data of anti-CD94 antibody

Rat Anti-CD94 Monoclonal Antibody – Cat# MBS520254

Other Notes

Small volumes of anti-CD94 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for CD94 purchase

MBS520254 is an antibody targeting CD94. Also known as Anti-Mouse CD94, PE, (clone: 15F.18D1), (rat IgG1k). Reactive in Mouse. Host: Rat.

Additional Details

NCBI/Uniprot data below describe general gene information for CD94. It may not necessarily be applicable to this product.

NCBI GI #
2995204
NCBI GeneID
3824
NCBI Accession #
CAA74663.1
UniProt Primary Accession #
Q13241
UniProt Secondary Accession #
O43321; O43773; Q9UBE3; Q9UEQ0
UniProt Related Accession #
Q13241
NCBI Official Full Name
CD94
NCBI Official Synonym Full Names
killer cell lectin-like receptor subfamily D, member 1
NCBI Official Symbol
KLRD1
NCBI Official Synonym Symbols
CD94
UniProt Protein Name
Natural killer cells antigen CD94
UniProt Synonym Protein Names
KP43; Killer cell lectin-like receptor subfamily D member 1; NK cell receptor
Protein Family
Natural killer cells antigen
UniProt Gene Name
KLRD1
UniProt Synonym Gene Names
CD94
UniProt Entry Name
KLRD1_HUMAN
NCBI Protein Information
natural killer cells antigen CD94; KP43; CD94 antigen; NK cell receptor

NCBI Summary for CD94

Natural killer (NK) cells are a distinct lineage of lymphocytes that mediate cytotoxic activity and secrete cytokines upon immune stimulation. Several genes of the C-type lectin superfamily, including members of the NKG2 family, are expressed by NK cells and may be involved in the regulation of NK cell function. KLRD1 (CD94) is an antigen preferentially expressed on NK cells and is classified as a type II membrane protein because it has an external C terminus. Three transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
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UniProt Comments for CD94

Function: Plays a role as a receptor for the recognition of MHC class I HLA-E molecules by NK cells and some cytotoxic T-cells.

Subunit structure: Can form disulfide-bonded heterodimer with NKG2 family members. Ref.8 Ref.9 Ref.10

Subcellular location: Membrane; Single-pass type II membrane protein.

Tissue specificity: Natural killer cells.

Sequence similarities: Contains 1 C-type lectin domain.
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Research Articles on CD94

1. Studies indicate that HLA-E interacts with CD94/NKG2 receptors expressed mainly on the surface of natural killer (NK) cells, thus confining its role to the regulation of NK-cell function.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Pathways associated with anti-CD94 antibody

 Products by Pathway  Pathway Diagram
 Adaptive Immune System Pathway antibodies  Adaptive Immune System Pathway Diagram
 Antigen Processing And Presentation Pathway antibodies  Antigen Processing And Presentation Pathway Diagram
 Antigen Processing And Presentation Pathway antibodies  Antigen Processing And Presentation Pathway Diagram
 DAP12 Interactions Pathway antibodies  DAP12 Interactions Pathway Diagram
 DAP12 Signaling Pathway antibodies  DAP12 Signaling Pathway Diagram
 Graft-versus-host Disease Pathway antibodies  Graft-versus-host Disease Pathway Diagram
 Graft-versus-host Disease Pathway antibodies  Graft-versus-host Disease Pathway Diagram
 Immune System Pathway antibodies  Immune System Pathway Diagram
 Immunoregulatory Interactions Between A Lymphoid And A Non-Lymphoid Cell Pathway antibodies  Immunoregulatory Interactions Between A Lymphoid And A Non-Lymphoid Cell Pathway Diagram
 Innate Immune System Pathway antibodies  Innate Immune System Pathway Diagram

Diseases associated with anti-CD94 antibody

 Disease Name  Pubmed Publications
 Neoplasms Antibodies  >75 publications with CD94 and Neoplasms
 Lymphoma Antibodies  >16 publications with CD94 and Lymphoma
 Skin Diseases Antibodies  >15 publications with CD94 and Skin Diseases
 Inflammation Antibodies  >13 publications with CD94 and Inflammation
 Neoplasms, Experimental Antibodies  >11 publications with CD94 and Neoplasms, Experimental
 Cardiovascular Diseases Antibodies  >7 publications with CD94 and Cardiovascular Diseases
 Liver Diseases Antibodies  >7 publications with CD94 and Liver Diseases
 Nervous System Diseases Antibodies  >6 publications with CD94 and Nervous System Diseases
 Kidney Diseases Antibodies  >4 publications with CD94 and Kidney Diseases
 Demyelinating Diseases Antibodies  >4 publications with CD94 and Demyelinating Diseases

Organs/Tissues associated with anti-CD94 antibody

 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >435 publications with CD94 and Blood
 Placenta Antibodies  >19 publications with CD94 and Placenta
 Liver Antibodies  >15 publications with CD94 and Liver
 Uncharacterized Tissue Antibodies  >1 publications with CD94 and Uncharacterized Tissue
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