NGFR Antibody – Mouse Monoclonal

Nerve growth factor receptor contains an extracellular domain containing four 40-amino acid repeats with 6 cysteine residues at conserved positions followed by a serine/threonine-rich region, a single transmembrane domain, and a 155-amino acid cytoplasmic domain. The cysteine-rich region contains the nerve growth factor binding domain. [provided by RefSeq, Jul 2008]

Function: Plays a role in the regulation of the translocation of GLUT4 to the cell surface in adipocytes and skeletal muscle cells in response to insulin, probably by regulating RAB31 activity, and thereby contributes to the regulation of insulin-dependent glucose uptake

By similarity. Low affinity receptor which can bind to NGF, BDNF, NT-3, and NT-4. Can mediate cell survival as well as cell death of neural cells. Ref.11

Subunit structure: Homodimer; disulfide-linked. Interacts with p75NTR-associated cell death executor. Interacts with TRAF2, TRAF4, TRAF6, PTPN13 and RANBP9. Interacts through TRAF6 with SQSTM1 which bridges NGFR to NTRK1. Interacts with BEX1 and NGFRAP1/BEX3. Interacts with KIDINS220 and NTRK1. Can form a ternary complex with NTRK1 and KIDINS220 and this complex is affected by the expression levels of KIDINS220. An increase in KIDINS220 expression leads to a decreased association of NGFR and NTRK1. Interacts with NTRK2; may regulate the ligand specificity of the NTRK2 receptor. Interacts (via death domain) with RAB31

By similarity. Interacts with LINGO1. Ref.6 Ref.7 Ref.8 Ref.9 Ref.10 Ref.11

Subcellular location: Membrane; Single-pass type I membrane protein.

Domain: Death domain is responsible for interaction with RANBP9.The extracellular domain is responsible for interaction with NTRK1

By similarity.

Post-translational modification: N- and O-glycosylated. Ref.12O-linked glycans consist of Gal1-3GalNAc core elongated by 1 or 2 NeuNAc.Phosphorylated on serine residues.

Sequence similarities: Contains 1 death domain.Contains 4 TNFR-Cys repeats.