CDCrel-1 Antibody – Mouse Monoclonal

Function: Filament-forming cytoskeletal GTPase

By similarity. Involved in cytokinesis

Potential. May play a role in platelet secretion. Ref.7

Subunit structure: Septins polymerize into heterooligomeric protein complexes that form filaments, and can associate with cellular membranes, actin filaments and microtubules. GTPase activity is required for filament formation

By similarity. Interacts with SEPT2 and SEPT5. Interaction with SEPT4 not detected. In platelets, associated with a complex containing STX4

By similarity. Interacts with PARK2. This interaction leads to SEPT5 ubiquitination and degradation. Ref.5 Ref.6

Subcellular location: Cytoplasm

By similarity. Cytoplasm › cytoskeleton

By similarity.

Developmental stage: Detected at 17 dpc in the brain. Expression increases during postnatal life and reaches a plateau at approximately P10 (at protein level). Ref.6

Disruption phenotype: Mice have a normal life-span and show no apparent abnormalities, including synaptic properties and hippocampal neuron growth. In platelets, hyperresponsive degranulation phenotype. Ref.6 Ref.7

Sequence similarities: Belongs to the septin family.