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CD34 Antibody – Rat Monoclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS520550

progenitor cells. The antibody recognizes a neuraminidase sensitive epitope on endothelium in vivo, particularly on small vessels and neoformed capillaries and developing vascular structures in embryonal structures. The antibody reacts with hematopoietic… More details

$435 / 0.25 mg +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
CD34, Monoclonal Antibody
Full Product Name
Anti-Mouse CD34, Purified (Clone MEC14.7) (rat IgG2a)
Product Gene Name
anti-CD34 antibody
Product Synonym Names
CD34, Purified (Clone MEC14.7) (rat IgG2a); Anti-Mouse CD34 Monoclonal Antibody
Clonality
Monoclonal
Isotype
Rat IgG2a
Clone Number
MEC 14.7
Host
Rat
Species Reactivity
Mouse
Form/Format
Purified
Concentration
1.0 mg/ml (lot specific)
Specificity
CD34 (mucosialin; sialomucin) (Mouse CD34)
Preparation and Storage
For all formats, store at 4 degree C. DO NOT FREEZE PE conjugates. For long term storage (Ascites, Purified, Biotin, FITC), aliquot and freeze unused portion at -20 degree C in volumes appropriate for single usage. Avoid freeze/thaw cycles.
Molecular Weight
40,716 Da
Chromosome Location
Chromosome: 1; NC_000001.10 (208059883..208084742, complement). Location: 1q32
OMIM
142230
3D Structure
ModBase 3D Structure for P28906
Presentation
Purified IgG buffered in PBS and 0.02% NaN3. (Purified from ascitic fluid via Protein G Chromatography).
Applications Tested/Suitable for anti-CD34 antibody
Immunohistochemistry (IHC), Flow Cytometry (FC/FACS), ELISA (EIA), Western Blot (WB), Immunoprecipitation (IP)

Testing Data of anti-CD34 antibody

Rat Anti-CD34 Monoclonal Antibody – Cat# MBS520550

Other Notes

Small volumes of anti-CD34 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for CD34 purchase

MBS520550 is an antibody targeting CD34. Also known as Anti-Mouse CD34, Purified (Clone MEC14.7) (rat IgG2a). Reactive in Mouse. Host: Rat.

Additional Details

NCBI/Uniprot data below describe general gene information for CD34. It may not necessarily be applicable to this product.

NCBI GI #
264769
NCBI GeneID
947
NCBI Accession #
AAB25223.1
UniProt Primary Accession #
P28906
UniProt Secondary Accession #
Q15970; Q15971; Q5JTA3; Q5JTA4; Q9UJB1; A8K664
UniProt Related Accession #
P28906
NCBI Official Full Name
CD34
NCBI Official Synonym Full Names
CD34 molecule
NCBI Official Symbol
CD34
UniProt Protein Name
Hematopoietic progenitor cell antigen CD34
Protein Family
Hematopoietic progenitor cell antigen
UniProt Gene Name
CD34
UniProt Entry Name
CD34_HUMAN
NCBI Protein Information
hematopoietic progenitor cell antigen CD34; CD34 antigen

NCBI Summary for CD34

The protein encoded by this gene may play a role in the attachment of stem cells to the bone marrow extracellular matrix or to stromal cells. This single-pass membrane protein is highly glycosylated and phosphorylated by protein kinase C. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2011]
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UniProt Comments for CD34

Function: Possible adhesion molecule with a role in early hematopoiesis by mediating the attachment of stem cells to the bone marrow extracellular matrix or directly to stromal cells. Could act as a scaffold for the attachment of lineage specific glycans, allowing stem cells to bind to lectins expressed by stromal cells or other marrow components. Presents carbohydrate ligands to selectins.

Subcellular location: Membrane; Single-pass type I membrane protein.

Tissue specificity: Selectively expressed on hematopoietic progenitor cells and the small vessel endothelium of a variety of tissues.

Developmental stage: On early hematopoietic progenitor cells.

Post-translational modification: Highly glycosylated.Phosphorylated on serine residues by PKC. Ref.10

Sequence similarities: Belongs to the CD34 family.

Sequence caution: The sequence AAA03181.1 differs from that shown. Reason: Erroneous initiation.
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Research Articles on CD34

1. CD34+ mononuclear cell mobilization is significantly impaired in patients with recurring atrial fibrillation after radiofrequency catheter ablation.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Pathways associated with anti-CD34 antibody

 Products by Pathway  Pathway Diagram
 Adaptive Immune System Pathway antibodies  Adaptive Immune System Pathway Diagram
 C-MYB Transcription Factor Network Pathway antibodies  C-MYB Transcription Factor Network Pathway Diagram
 Cell Adhesion Molecules (CAMs) Pathway antibodies  Cell Adhesion Molecules (CAMs) Pathway Diagram
 Cell Adhesion Molecules (CAMs) Pathway antibodies  Cell Adhesion Molecules (CAMs) Pathway Diagram
 Hematopoietic Cell Lineage Pathway antibodies  Hematopoietic Cell Lineage Pathway Diagram
 Hematopoietic Cell Lineage Pathway antibodies  Hematopoietic Cell Lineage Pathway Diagram
 Immune System Pathway antibodies  Immune System Pathway Diagram
 Immunoregulatory Interactions Between A Lymphoid And A Non-Lymphoid Cell Pathway antibodies  Immunoregulatory Interactions Between A Lymphoid And A Non-Lymphoid Cell Pathway Diagram

Diseases associated with anti-CD34 antibody

 Disease Name  Pubmed Publications
 Neoplasms Antibodies  >11069 publications with CD34 and Neoplasms
 Bone Marrow Diseases Antibodies  >2556 publications with CD34 and Bone Marrow Diseases
 Carcinoma Antibodies  >1783 publications with CD34 and Carcinoma
 Skin Diseases Antibodies  >1688 publications with CD34 and Skin Diseases
 Necrosis Antibodies  >1066 publications with CD34 and Necrosis
 Adenocarcinoma Antibodies  >835 publications with CD34 and Adenocarcinoma
 Breast Neoplasms Antibodies  >802 publications with CD34 and Breast Neoplasms
 Anemia Antibodies  >794 publications with CD34 and Anemia
 Skin Neoplasms Antibodies  >699 publications with CD34 and Skin Neoplasms
 Liver Diseases Antibodies  >647 publications with CD34 and Liver Diseases

Organs/Tissues associated with anti-CD34 antibody

 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >15489 publications with CD34 and Blood
 Bone Antibodies  >9353 publications with CD34 and Bone
 Bone Marrow Antibodies  >8839 publications with CD34 and Bone Marrow
 Vascular Antibodies  >4776 publications with CD34 and Vascular
 Muscle Antibodies  >2283 publications with CD34 and Muscle
 Umbilical Cord Antibodies  >1575 publications with CD34 and Umbilical Cord
 Liver Antibodies  >1486 publications with CD34 and Liver
 Skin Antibodies  >1344 publications with CD34 and Skin
 Lung Antibodies  >981 publications with CD34 and Lung
 Heart Antibodies  >902 publications with CD34 and Heart
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