CD200R Antibody – Rat Monoclonal

anti-mouse CD200R monoclonal antibody reacts with CD200R, a highly conserved type I membrane glycoprotein that is expressed on a variety of cell types from the myeloid/monocytic lineage, including macrophages, dendritic cells, basophils, mast cells and polarized Th2 cells. CD200R is very similar in structure to CD200, except that it has a larger cytoplasmic domain (67 aa). CD200R is also referred to as CD200R1. Three homologues designated CD200R2 (CD200RLc), CD200R3 (CD200RLb) and CD200R4 (CD200RLa) have also been described, each containing a short (15aa) cytoplasmic tail lacking putative ITIM motifs. It is thought that CD200R1 acts as an inhibitory receptor in contrast to CD200R2-4, which appear to be activating receptors. CD200R1-4 show variable expression in different tissues. CD200 is the ligand for CD200R, and CD200/CD200R interactions are thought to play an important role in autoimmune disease and transplant rejection. This clone is suitable for use in flow cytometry

Small volumes of anti-CD200R antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

MBS520583 is an antibody targeting CD200R. Also known as Anti-Mouse CD200R, Biotin (Clone OX110) (rat IgG2a). Reactive in Mouse. Host: Rat.