Hace 1 Antibody – Mouse Monoclonal

Anti-Human HACE 1 monoclonal antibody binds HACE 1 (HECT domain and ankyrin repeat containing), an E3 ubiquitin protein ligase 1 that has ubiquitin ligase activity. HACE 1 was found to be a tumor suppressor which is down-regulated in human Wilm's tumor. HACE1 is frequently downregulated in human tumors and maps to a region of chromosome 6q21 implicated in multiple human cancers. Genetic inactivation of HACE1 results in the development of spontaneous, late-onset cancer. A second hit from either environmental triggers or genetic heterozygosity of another tumor suppressor, p53, markedly increases tumor incidence in a HACE 1-deficient background. Re-expression of HACE1 in human tumor cells directly abrogates in vitro and in vivo tumor growth, whereas downregulation of HACE1 via siRNA allows non-tumorigenic human cells to form tumors in vivo. Mechanistically, the tumor-suppressor function of HACE1 is dependent on its E3 ligase activity. HACE1 controls adhesion-dependent growth and cell cycle progression during cell stress by influencing the degradation of cyclin D1.

Small volumes of anti-Hace 1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

MBS520631 is an antibody targeting Hace 1. Also known as Anti-Human Hace 1, Purified (clone: 8D3) (Mouse IgG,k). Reactive in Human. Host: Mouse.