Munc18-1 (STXBP1) Antibody – Mouse Monoclonal

Syntaxin-binding protein 1 (STXBP1) or munc18-1 is an abundant neuronal protein that tightly binds to synaptic fusion protein syntaxin and functions in synaptic vesicle docking and fusion. Munc-18 is the mammalian homologue of the unc-18 protein, which can be found in organisms such as C. elegans, and is a member of the Sec1/Munc18- like (SM) protein family. There are six known Munc-18 family members in mammalian cells: Munc18-1 (STXBP1) and STXBP2-6. Munc18-1 in particular is highly expressed in brain, spinal cord and axons. Munc18-1 is known to interact with syntaxin 1, 2, and 3 but not with syntaxin 4. Syntaxin 1A is as a key member of the SNARE core complex and is important for synaptic vesicle docking, fusion and ultimately exocytosis. Munc18-1 modulates neurotransmission through its interaction with Syntaxin 1 and is thought to help restrict fusion of vesicles to specific sites of the plasma membrane. Deletion of munc18-1 leads to defects in secretory vesicle docking and the absence of neurotransmitter release. Defects in munc18-1 are the cause of epileptic encephalopathy early infantile type 4 (EIEE4). Affected individuals have neonatal or infantile onset of seizures and suppression-bursts.

Small volumes of anti-STXBP1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

MBS520663 is an antibody targeting STXBP1. Also known as Anti-Human Munc18-1(STXBP1), HRPO, (clone: 1B9) (Mouse IgG2b, k). Reactive in Human. Host: Mouse.