C5A/C5A Antibody – Mouse Monoclonal

Anti-Human C5a reacts with neo-epitope on C5a (des-Arg) that is formed upon cleavage of C5 into C5a and C5b. C5 is involved in the activation of the lythic pathway within the complement system which is an important factor in innate immunity. The complement pathways can be divided in the activation pathways and lytic pathway. The activation pathways lead via C3 to the cleavage of the fifth complement component C5. C5a induces smooth muscle contraction, increases vascular permeability, causes degranulation of mast cells and basophils, and release of lysosomal enzymes. In addition C5a stimulates the directed migration of neutrophils, eosinophils, basophils and monocytes. Recent studies indicate the modulation of the acute-phase response in liver and an overall immune response by inducing synthesis of cytokines such as TNF-alpha, IL-1beta, IL-6 and IL-8.

1. Nozaki, M et al; Drusen complement components C3a and C5a promote choroidal neovascularisation. PNAS 2006, 103: 2328
2. Oppermann, M., Kurts, C., Zierz, R., Quentin, E., Weber, M. H., and Götze, O. (1991) Kidney Int. 40, 939947
3 Oppermann, M., Höpken, U., and Götze, O. (1992) Immunopharm. 24, 119134
4. Oppermann, M., Haubitz, M., Quentin, E., and Götze, O. (1988) Klin. Wochenschr. 66, 857864
5. Nezlin, R., Freywald, A., and Oppermann, M. (1993) Mol. Immunol. 30, 935940
6. Ammon, H. P. T., Ege, W., Oppermann, M., Göpel, W., and Eisele, S. (1995) Anal. Chem. 67, 466471
7. Püschel, G. P., Dieter, P., Muschol, W., Oppermann, M., Hülsmann, M., SchulzeSpecking, A., Götze, O., Decker, K., and Jungermann, K. (1991) Prostanoid production in Kupffer cells: A step in the increase in glucose and lactate output and reduction of flow by anaphylatoxins in perfused rat liver. In Wisse, E., Knook, D. L., and Decker, K., editors. Cells of the hepatic sinusoid, Leiden, Kupffer Cell Foundation
8. Lhotta, K., Würzner, R., Kronenberg, F., Oppermann, M., and Konig, P. (1998) Kidney Int. 53, 10441051
9. Oppermann, M., Schulze, M., Götze, O. (1991) A sensitive enzyme immunoassay for the quantitation of human C5a/C5a(d

Small volumes of anti-C5a/C5a antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

MBS520717 is an antibody targeting C5a/C5a. Also known as Anti-Human C5a/C5a(desArg)(Neo-Epitope), Biotin (clone: C17/5), (Mouse IgG1 K). Reactive in Human. Host: Mouse.