CD11b/c Antibody – Mouse Monoclonal

The anti-rat CD11b/c monoclonal antibody recognizes most macrophages including resident peritoneal macrophages, kupffer cells, but only approximately 35% of alveolar macrophages (2). It also labels dendritic cells extensively, granulocytes and cells with morphology of microglia in the brain. It precipitates three polypeptides of M.W. 160, 103 and 95kDa. OX-42 inhibits complement mediated rosettes and is probably the rat equivalent of the human receptor for iC3b called CR3. The anti-rat CD11b/c mAb should prove useful in the recognition of macrophages and microglia.

This clone is reported to work with frozen and paraffin sections (3); in vivo and in vitro functional tests (4, 5, 6); and cryostat sections (5).

1) Aihara, N. et al. (1995) J. Neurotrauma. 12:53-63. 2) Robinson, A.P. et al. (1986) Immunology. 57:239-247. 3) Whiteland J.L. et al. (1995) J. Histochem and Cytochem. 43:313-320. 4) Issekutz, A. C. and T.B. Issekutz, (1992) Immunology. 76:655-661. 5) Yamazaki, T. et al. (1993) Am. J. of Pathology. 143:410-418. 6) Tamatani, T. et al. (1991) Eur. J. Immunol. 21:627-633. 7) Joan Y. et al. (2009) Am J Physiol Regul Integr Comp Physiol. 297:R1532-R1545. 8) Zheng Gen Piao et al. (2005) Pain. 121:219-231. 9) Abbadie C. et al. (2003) PNAS. 100:7947-7952. 10) Lee. et al. (2010) Molecular Pain. 6:79. 11) Summy-Long, J.Y. et al. (2008) Journal of Neuroendocrinology. 20:1224-1232.

Small volumes of anti-CD11b/c antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

MBS520874 is an antibody targeting CD11b/c. Also known as Anti-Rat CD11b/c, Low Endotoxin (Clone OX-42) (Mouse IgG2a). Reactive in Rat. Host: Mouse.