C3/C3B/iC3b Antibody – Mouse

The Purified Anti-Human/Mouse Complement Component C3 monoclonal antibody (Clone: 6C9) reacts with human and mouse C3 as well as the breakdown products C3b and iC3b. C3 is the most abundant complement protein in serum. C3 and its cleavage products, C3a and C3b, play a central role in the complement activation cascade. C3b forms an integral part of the C3 and C5 convertases as it promotes complement activation and the subsequent formation of the membrane attack complex. C3a possesses anaphlatoxic as well as various immunoregulatory properties.
Also, C3 has been implicated in developmental and non-imflammatory process such as hematopoiesis, skeletal and vascular development and reproduction.

1) Kremmer E, Thierfelder S, Felber E, et al. (1990) Monoclonal antibodies to complement components without the need of their prior purification. II. Antibodies to mouse C3 and C4. Hybridoma. 9(4):309-17. 2) Cortes C, Ferreira VP, Pangburn MK. (2011) Native properdin binds to Chlamydia pneumoniae and promotes complement activation. Infect Immun. 79(2):724-31. 3) Fridkis-Hareli M, Storek M, Mazsaroff I, et al. (2011) Design and development of TT30, a novel C3d-targeted C3/C5 convertase inhibitor for treatment of human complement alternative pathway-mediated diseases. Blood. 118(17):4705-13.

Small volumes of anti-C3/C3b/iC3b antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

MBS520889 is an antibody targeting C3/C3b/iC3b. Also known as Anti-Human/Mouse C3/C3b/iC3b, (Purified) (Clone: 6C9) (Mouse IgG1). Reactive in Mouse, Human. Host: Mouse.