Gm Ganglioside Activator (GM2A) Antibody – Rabbit Polyclonal

The GM2 ganglioside activator (GM2A) protein is a small glycolipid transport protein. It acts as a substrate cofactor for the lysosomal enzyme beta-hexosaminidase A. Beta-hexosaminidase A, together with GM2A, catalyzes the degradation of the ganglioside GM2, and other molecules containing terminal N-acetyl hexoseamines. It binds molecules of ganglioside GM2, extracts them from membranes, and presents them to beta-hexosaminidase A for cleavage of N-acetyl-D-galactosamine and conversion to GM3. Mutations in the GM2A gene result in a rare ABvariant form of GM2 gangliosidosis, a recessively inherited disorder characterized by excessive neuronal accumulation of GM2 and related glycolipids. Individuals with this disorder exhibit symptoms and pathology identical to Tay-Sachs disease and Sandhoff disease.

Small volumes of anti-GM Ganglioside Activator (GM2A) antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

MBS524120 is an antibody targeting GM Ganglioside Activator (GM2A). Also known as Anti-Mouse GM Ganglioside Activator (GM2A), Purified, (Polyclonal) (Rabbit IgG). Reactive in Mouse. Host: Rabbit.