Prolactin Receptor (PRLR) Antibody – Rabbit Polyclonal

This gene encodes a receptor for the anterior pituitary hormone, prolactin, and belongs to the type I cytokine receptor family. Prolactin-dependent signaling occurs as the result of ligand-induced dimerization of the prolactin receptor. Several alternatively spliced transcript variants encoding different membrane-bound and soluble isoforms have been described for this gene, which may function to modulate the endocrine and autocrine effects of prolactin in normal tissue and cancer. [provided by RefSeq, Feb 2011]

Function: This is a receptor for the anterior pituitary hormone prolactin (PRL). Acts as a prosurvival factor for spermatozoa by inhibiting sperm capacitation through suppression of SRC kinase activation and stimulation of AKT. Isoform 4 is unable to transduce prolactin signaling. Isoform 6 is unable to transduce prolactin signaling. Ref.6 Ref.7

Subunit structure: Homodimer upon hormone binding. Interacts with SMARCA1. Interacts with GH1. Interacts with CSH. Interacts with NEK3 and VAV2 and this interaction is prolactin-dependent. Ref.4 Ref.13 Ref.14 Ref.15 Ref.17

Subcellular location: Membrane; Single-pass type I membrane protein Ref.4 Ref.6. Isoform 7: Secreted Ref.4 Ref.6.

Tissue specificity: Expressed in breast, placenta, kidney, liver and pancreas. Ref.4 Ref.6

Domain: The WSXWS motif appears to be necessary for proper protein folding and thereby efficient intracellular transport and cell-surface receptor binding.The box 1 motif is required for JAK interaction and/or activation.

Sequence similarities: Belongs to the type I cytokine receptor family. Type 1 subfamily.Contains 2 fibronectin type-III domains.