Rabbit Anti-MC4R Polyclonal Antibody – Cat# MBS524440

(2ug/ml) staining of Human Cerebellum (A) and Rat Brain (B) lysates (35 ug protein in RIPA buffer).
Primary incubation was 1 hour. Detected by chemiluminescence.

Melanocortin Receptor 4 (MC4R) Antibody – Rabbit Polyclonal

Name: MC4R Antibody; Polyclonal; Rabbit; Mouse/Rat/Human-Reactive; MyBioSource
Brand: MyBioSource
SKU: MBS524440
Price: 570 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS524440

Melanocortin 4 receptor is a G-protein-coupled receptor from the melanocortin receptor family that binds amelanocyte stimulating hormon ~(a-MSH). These receptors transduce signals provided by a-MSH by coupling to the G-protein and activating adenyl ate… More details

$570 / 0.1 mg +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

Melanocortin receptor 4 (MC4R), Polyclonal Antibody

Full Product Name

Anti-Mouse Melanocortin receptor 4, Affinity Purified, (Polyclonal), (Rabbit IgG)

Product Gene Name

anti-MC4R antibody

Clonality

Polyclonal

Isotype

IgG

Host

Rabbit

Species Reactivity

Mouse, Rat, Human

Form/Format

Affinity Purified

Specificity

This antibody is specific for mouse, rat, and human MC4R.

Preparation and Storage

Store at + 4°C. For long term storage, aliquot and freeze unused portion at -20°C in volumes appropriate for single usage. Avoid freeze/thaw cycles.

Molecular Weight

36,943 Da

OMIM

155541

Presentation

100 ug (MBS524440) or 20 ug (MBS524440-S) purified IgG buffered in PBS and 0.02% NaN3• (Purified from serum via Affinity Chromatography). For maximum recovery of contents, spin down tube before use.

Immunogen

15 amino acid synthetic peptide located within the 1st extracellular domain of mouse MC4R.

Applications Tested/Suitable for anti-MC4R antibody

ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC)-Paraffin

Application Notes for anti-MC4R antibody

This antibody is suitable for use in ELISA, Western Blot (2 ug/mL) and Immunohistochemistry with FFPE sections (10 ug/mL). This antibody has not been tested in other applications.

N.B Appropriate control samples should always be included in any labeling studies
*For For optimal results in various applications, it is recommended that each investigator determine dilutions appropriate for individual use.

Other Notes

Small volumes of anti-MC4R antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for MC4R purchase

MBS524440 is an antibody targeting MC4R. Also known as Anti-Mouse Melanocortin receptor 4, Affinity Purified, (Polyclonal), (Rabbit IgG). Reactive in Mouse, Rat, Human. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for MC4R. It may not necessarily be applicable to this product.

NCBI GI #

119508433

NCBI GeneID

4160

NCBI Accession #

NP_005903.2

UniProt Secondary Accession #

Q16317; Q3MIJ6; B2RAC3

UniProt Related Accession #

P32245

GenBank Nucleotide #

NM_005912.2

NCBI Official Full Name

melanocortin receptor 4

NCBI Official Synonym Full Names

melanocortin 4 receptor

NCBI Official Symbol

MC4R

UniProt Protein Name

Melanocortin receptor 4

Protein Family

Melanocortin receptor

UniProt Gene Name

MC4R

UniProt Synonym Gene Names

MC4-R

UniProt Entry Name

MC4R_HUMAN

NCBI Protein Information

melanocortin receptor 4

NCBI Summary for MC4R

The protein encoded by this gene is a membrane-bound receptor and member of the melanocortin receptor family. The encoded protein interacts with adrenocorticotropic and MSH hormones and is mediated by G proteins. This is an intronless gene. Defects in this gene are a cause of autosomal dominant obesity. [provided by RefSeq, Jan 2010]

UniProt Comments for MC4R

MC4R: receptor specific to the heptapeptide core common to adrenocorticotropic hormone and alpha-, beta-, and gamma-MSH. A G-protein coupled receptor that stimulates adenylate cyclase. Defects are a cause of autosomal dominant obesity

Protein type: Membrane protein, multi-pass; GPCR, family 1; Receptor, GPCR; Membrane protein, integral

Chromosomal Location of Human Ortholog: 18q22

Cellular Component: integral to membrane; nucleus; plasma membrane

Molecular Function: melanocortin receptor activity; melanocyte stimulating hormone receptor activity; neuropeptide binding; peptide hormone binding; protein binding; ubiquitin protein ligase binding

Biological Process: diet induced thermogenesis; energy reserve metabolic process; feeding behavior; G-protein signaling, coupled to cAMP nucleotide second messenger; insulin secretion; positive regulation of bone resorption; positive regulation of cAMP biosynthetic process; response to insulin stimulus

Disease: Obesity

Research Articles on MC4R

1. The interaction between FTO and MC4R polymorphisms is associated with the development of PCOS.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-MC4R antibody

Reference Product	PubMed Publications
POMC antibody	>387 publications with MC4R and POMC
AGRP antibody	>145 publications with MC4R and AGRP
MC1R antibody	>81 publications with MC4R and MC1R
LEP antibody	>29 publications with MC4R and LEP
CRH antibody	>16 publications with MC4R and CRH
GIPR antibody	>7 publications with MC4R and GIPR
GLP1R antibody	>5 publications with MC4R and GLP1R

Pathways associated with anti-MC4R antibody

Products by Pathway	Pathway Diagram
Class A/1 (Rhodopsin-like Receptors) Pathway antibodies	Class A/1 (Rhodopsin-like Receptors) Pathway Diagram
G Alpha (s) Signalling Events Pathway antibodies	G Alpha (s) Signalling Events Pathway Diagram
GPCR Downstream Signaling Pathway antibodies	GPCR Downstream Signaling Pathway Diagram
GPCR Ligand Binding Pathway antibodies	GPCR Ligand Binding Pathway Diagram
GPCRs, Class A Rhodopsin-like Pathway antibodies	GPCRs, Class A Rhodopsin-like Pathway Diagram
Neuroactive Ligand-receptor Interaction Pathway antibodies	Neuroactive Ligand-receptor Interaction Pathway Diagram
Neuroactive Ligand-receptor Interaction Pathway antibodies	Neuroactive Ligand-receptor Interaction Pathway Diagram
Peptide GPCRs Pathway antibodies	Peptide GPCRs Pathway Diagram
Peptide Ligand-binding Receptors Pathway antibodies	Peptide Ligand-binding Receptors Pathway Diagram
Signal Transduction Pathway antibodies	Signal Transduction Pathway Diagram

Diseases associated with anti-MC4R antibody

Disease Name	Pubmed Publications
Obesity Antibodies	>703 publications with MC4R and Obesity
Body Weight Antibodies	>651 publications with MC4R and Body Weight
Weight Gain Antibodies	>101 publications with MC4R and Weight Gain
Weight Loss Antibodies	>96 publications with MC4R and Weight Loss
Hyperphagia Antibodies	>77 publications with MC4R and Hyperphagia
Insulin Resistance Antibodies	>62 publications with MC4R and Insulin Resistance
Hyperinsulinism Antibodies	>50 publications with MC4R and Hyperinsulinism
Cardiovascular Diseases Antibodies	>47 publications with MC4R and Cardiovascular Diseases
Hypertension Antibodies	>46 publications with MC4R and Hypertension
Inflammation Antibodies	>39 publications with MC4R and Inflammation

Organs/Tissues associated with anti-MC4R antibody

Organ/Tissue Name	Pubmed Publications
Brain Antibodies	>345 publications with MC4R and Brain