Platelet Antibodies IgA (PA-IgA) ELISA Kit for Porcine

PRDM16: binds DNA and functions as a transcriptional regulator. A repressor of TGF-beta signaling. Functions in the differentiation of brown adipose tissue (BAT) which is specialized in dissipating chemical energy in the form of heat in response to cold or excess feeding while white adipose tissue (WAT) is specialized in the storage of excess energy and the control of systemic metabolism. Together with CEBPB, regulates the differentiation of myoblastic precursors into brown adipose cells. Interacts with HDAC1, SKI, SMAD2 and SMAD3; the interaction with SKI promotes the recruitment of SMAD3-HDAC1 complex on the promoter of TGF-beta target genes. A chromosomal aberration involving PRDM16 is found in myelodysplastic syndrome (MDS) and acute myeloid leukemia (AML). Reciprocal translocation t(1;3)(p36;q21). Isoform 4 is specifically expressed in adult T-cell leukemia. Four human isoforms are produced by alternative promoter usage and alternative splicing

Protein type: Methyltransferase, protein lysine, predicted; C2H2-type zinc finger protein

Cellular Component: transcriptional repressor complex; nucleus

Molecular Function: protein binding; transcription activator binding; nucleic acid binding; DNA binding; sequence-specific DNA binding; metal ion binding; transcription coactivator activity; SMAD binding

Biological Process: tongue development; transcription, DNA-dependent; somatic stem cell maintenance; positive regulation of transcription, DNA-dependent; stem cell maintenance; palate development; negative regulation of transcription from RNA polymerase II promoter; negative regulation of granulocyte differentiation; regulation of cellular respiration; neurogenesis; regulation of transcription, DNA-dependent; white fat cell differentiation; brown fat cell differentiation; cell differentiation; negative regulation of transforming growth factor beta receptor signaling pathway; negative regulation of transcription, DNA-dependent