TPCN1 Antibody – Rabbit Polyclonal

TPCN1: one of the major voltage-gated Ca(2+) channel (VDCC) across the plasma membrane. Highest expression found in the heart and kidney, and lowest expression found in the spleen. Each of the two internal repeats contains five hydrophobic transmembrane segments (S1, S2, S3, S5, S6) and one positively charged transmembrane segment (S4). S4 segments probably represent the voltage-sensor and are characterized by a series of positively charged amino acids at every third position. Two alternatively spliced human isoforms have been described.

Protein type: Membrane protein, multi-pass; Channel, calcium; Transporter; Membrane protein, integral; Transporter, ion channel

Chromosomal Location of Human Ortholog: 12q24.13

Cellular Component: lysosomal membrane; integral to membrane; plasma membrane; endosome membrane

Molecular Function: voltage-gated calcium channel activity; identical protein binding; protein binding

Biological Process: calcium ion transport; transmembrane transport