SLC4A5 Antibody – Rabbit Polyclonal

This gene encodes a member of the sodium bicarbonate cotransporter (NBC) family, part of the bicarbonate transporter superfamily. Sodium bicarbonate cotransporters are involved in intracellular pH regulation and electroneural or electrogenic sodium bicarbonate transport. This protein is thought to be an integral membrane protein. Multiple transcript variants encoding different isoforms have been found for this gene, but the biological validity of some variants has not been determined. [provided by RefSeq, Jul 2008]

SLC4A5: Mediates sodium- and bicarbonate-dependent electrogenic sodium bicarbonate cotransport, with a Na(+):HCO3(-) stoichiometry of 2:1. May have a housekeeping function in regulating the pH of tissues in which it is expressed. May play a role in mediating Na(+):HCO3(-) cotransport in hepatocytes and intrahepatic cholangiocytes. Also may be important in protecting the renal paranchyma from alterations in urine pH. Belongs to the anion exchanger (TC 2.A.31) family. 8 isoforms of the human protein are produced by alternative splicing.

Protein type: Membrane protein, integral; Transporter; Membrane protein, multi-pass; Transporter, SLC family

Chromosomal Location of Human Ortholog: 2p13

Cellular Component: integral to plasma membrane; apical plasma membrane; plasma membrane; integral to membrane

Molecular Function: inorganic anion exchanger activity; sodium:bicarbonate symporter activity

Biological Process: renal system process; cerebrospinal fluid secretion; regulation of gene expression; bicarbonate transport; retina development in camera-type eye; regulation of intracellular pH; regulation of systemic arterial blood pressure; epithelial cell development; ion transport; transmembrane transport; mitochondrion distribution