hnRPD Antibody – Rabbit Polyclonal

This gene belongs to the subfamily of ubiquitously expressed heterogeneous nuclear ribonucleoproteins (hnRNPs). The hnRNPs are nucleic acid binding proteins and they complex with heterogeneous nuclear RNA (hnRNA). These proteins are associated with pre-mRNAs in the nucleus and appear to influence pre-mRNA processing and other aspects of mRNA metabolism and transport. While all of the hnRNPs are present in the nucleus, some seem to shuttle between the nucleus and the cytoplasm. The hnRNP proteins have distinct nucleic acid binding properties. The protein encoded by this gene has two repeats of quasi-RRM domains that bind to RNAs. It localizes to both the nucleus and the cytoplasm. This protein is implicated in the regulation of mRNA stability. Alternative splicing of this gene results in four transcript variants. [provided by RefSeq, Jul 2008]

hnRNP D0: a ubiquitously expressed heterogeneous nuclear ribonucleoprotein (hnRNP). Implicated in the regulation of mRNA stability. Has two repeats of quasi-RRM domains that bind to RNAs. It localizes to both the nucleus and the cytoplasm. Four alternatively spliced transcript variants have been described.

Protein type: RNA splicing; RNA-binding

Chromosomal Location of Human Ortholog: 4q21

Cellular Component: nucleoplasm; ribonucleoprotein complex; cytosol; nucleus

Molecular Function: protein binding; RNA binding; nucleotide binding; telomeric DNA binding

Biological Process: nuclear mRNA splicing, via spliceosome; RNA processing; positive regulation of translation; regulation of transcription, DNA-dependent; transcription, DNA-dependent; RNA splicing; positive regulation of transcription, DNA-dependent; RNA catabolic process; gene expression; regulation of circadian rhythm; regulation of mRNA stability