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PKC Alpha (PKCA) Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS5312573

Protein kinase C alpha (PKCalpha), also known as PRKCA, refers to both a human gene and the protein that is encoded by it. Protein kinase C (PKC) is a family of serine- and threonine-specific protein kinases that can be activated by calcium and the second… More details

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Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Product Overview

Online Datasheet in PDF
Product Name
PKC Alpha (PKCA), Polyclonal Antibody
Full Product Name
PKC Alpha Antibody
Product Gene Name
anti-PKCA antibody
Product Synonym Names
Affinity Purified Rabbit Polyclonal PKC alpha Antibody; Polyclonal PKC alpha antibody; Anti-PKC alpha antibody; PKCD antibody; Protein kinase C gamma antibody; PKC zeta antibody; Protein Kinase C antibody; Protein kinase C alpha antibody; Protein kinase C beta 1 antibody; PKC gamma antibody; PRKCE antibody; PKCE antibody; kinase PKC alpha antibody; Protein kinase C epsilon antibody; PKC alpha antibody; PKC G antibody; PRKCB2 antibody; PKC A antibody; AAG6 antibody; PKCEA antibody; PKCG antibody; SCA14 antibody; Protein kinase C beta antibody; nPKC epsilon antibody; Protein kinase C beta type antibody; PRKCD antibody; PRKC A antibody; PKCA antibody; PKC B antibody; PKC2 antibody; PKC delta antibody; PKCC antibody; PRKCA antibody; PKCB antibody; Protein kinase C zeta antibody; PRKCB1 antibody; MGC41878 antibody; PRKCZ antibody; MGC129901 antibody; PRKACA antibody; Protein kinase C gamma type antibody; Protein kinase C delta antibody; Spinocerebellar ataxia 14 antibody; Aging associated gene 6 antibody; Protein kinase C beta 1 polypeptide antibody; PKC beta antibody; PKC epsilon antibody; Protein kinase C alpha type antibody; PRKC G antibody; MGC129900 antibody; MGC57564 antibody; PRKCG antibody; PRKCB antibody
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Form/Format
Lyophilized Form
Purity/Purification
Affinity Chromatography
Preparation and Storage
Store at 4 degree C for short term storage. For long term storage aliquot and store at -20 degree C. Avoid repeated freeze/thaw cycles.
3D Structure
ModBase 3D Structure for P04409
Immunogen
PKC alpha antibody was raised in Rabbit using a synthetic peptide corresponding to a sequence at the C-terminal of human PKC alpha, identical to the related rat and Rabbit sequences, as the immunogen

Product Categories/Family for anti-PKCA antibody

Proteases; Inhibitors; & Enzymes
Applications Tested/Suitable for anti-PKCA antibody
Western Blot (WB), Immunohistochemistry (IHC) Paraffin

Immunohistochemistry (IHC) of anti-PKCA antibody

Immunohistochemistry of paraffin-embedded section of Human Mammary Cancer Tissue
Rabbit Anti-PKCA Polyclonal Antibody – Cat# MBS5312573

Western Blot (WB) of anti-PKCA antibody

Western Blot using Hela Cell Lysate
Rabbit Anti-PKCA Polyclonal Antibody, Western Blot (WB) – Cat# MBS5312573

Other Notes

Small volumes of anti-PKCA antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for PKCA purchase

MBS5312573 is an antibody targeting PKCA. Also known as PKC Alpha Antibody. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for PKCA. It may not necessarily be applicable to this product.

NCBI GI #
27806089
NCBI GeneID
282001
UniProt Primary Accession #
P04409
UniProt Related Accession #
P04409
GenBank Nucleotide #
NP_776860.1
NCBI Official Full Name
protein kinase C alpha type
NCBI Official Synonym Full Names
protein kinase C alpha
NCBI Official Symbol
PRKCA
NCBI Official Synonym Symbols
PKRCA
UniProt Protein Name
Protein kinase C alpha type
Protein Family
Protein kinase
UniProt Gene Name
PRKCA
UniProt Synonym Gene Names
PKC-A; PKC-alpha
UniProt Entry Name
KPCA_BOVIN
NCBI Protein Information
protein kinase C alpha type

UniProt Comments for PKCA

PKCA: an AGC kinase of the PKC family. A classical PKC downstream of many mitogenic and receptors. Classical PKCs are calcium-dependent enzymes that are activated by phosphatidylserine, diacylglycerol and phorbol esters. Contains a pseudo-substrate autoinhibitory domain that binds to the catalytic domain preventing its activation in the absence of cofactors or activators.

Protein type: EC 2.7.11.13; Kinase, protein; Protein kinase, AGC; Oncoprotein; Protein kinase, Ser/Thr (non-receptor); AGC group; PKC family; Alpha subfamily

Cellular Component: cytoplasm; cytosol; intracellular; mitochondrial membrane; nucleus; perinuclear region of cytoplasm; plasma membrane

Molecular Function: ATP binding; protein binding; protein kinase C activity; zinc ion binding

Biological Process: adenylate cyclase activation; angiogenesis; apoptosis; cell adhesion; negative regulation of adenylate cyclase activity; peptidyl-serine phosphorylation; positive regulation of angiogenesis; positive regulation of cell adhesion; positive regulation of cell migration; positive regulation of endothelial cell proliferation; positive regulation of lipopolysaccharide-mediated signaling pathway; positive regulation of macrophage differentiation; positive regulation of mitotic cell cycle; protein amino acid phosphorylation
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Research Articles on PKCA

1. Mechanical stress induced biphasic and directional PKCalpha translocation

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-PKCA antibody

 Reference Product  PubMed Publications
 SRC antibody  >27 publications with PKCA and SRC
 RHOA antibody  >19 publications with PKCA and RHOA
 MARCKS antibody  >11 publications with PKCA and MARCKS
 SDC4 antibody  >9 publications with PKCA and SDC4
 MTOR antibody  >6 publications with PKCA and MTOR
 BRAF antibody  >1 publications with PKCA and BRAF
 GNB1 antibody  >1 publications with PKCA and GNB1

Pathways associated with anti-PKCA antibody

 Products by Pathway  Pathway Diagram
 AGE-RAGE Signaling Pathway In Diabetic Complications antibodies  AGE-RAGE Signaling Pathway In Diabetic Complications Diagram
 AGE-RAGE Signaling Pathway In Diabetic Complications antibodies  AGE-RAGE Signaling Pathway In Diabetic Complications Diagram
 Adrenergic Signaling In Cardiomyocytes Pathway antibodies  Adrenergic Signaling In Cardiomyocytes Pathway Diagram
 Adrenergic Signaling In Cardiomyocytes Pathway antibodies  Adrenergic Signaling In Cardiomyocytes Pathway Diagram
 African Trypanosomiasis Pathway antibodies  African Trypanosomiasis Pathway Diagram
 African Trypanosomiasis Pathway antibodies  African Trypanosomiasis Pathway Diagram
 Aldosterone Synthesis And Secretion Pathway antibodies  Aldosterone Synthesis And Secretion Pathway Diagram
 Aldosterone Synthesis And Secretion Pathway antibodies  Aldosterone Synthesis And Secretion Pathway Diagram
 Aldosterone-regulated Sodium Reabsorption Pathway antibodies  Aldosterone-regulated Sodium Reabsorption Pathway Diagram
 Aldosterone-regulated Sodium Reabsorption Pathway antibodies  Aldosterone-regulated Sodium Reabsorption Pathway Diagram

Diseases associated with anti-PKCA antibody

 Disease Name  Pubmed Publications
 Breast Neoplasms Antibodies  >63 publications with PKCA and Breast Neoplasms
 Nervous System Diseases Antibodies  >46 publications with PKCA and Nervous System Diseases
 Inflammation Antibodies  >41 publications with PKCA and Inflammation
 Necrosis Antibodies  >36 publications with PKCA and Necrosis
 Neoplasms, Experimental Antibodies  >36 publications with PKCA and Neoplasms, Experimental
 Cardiovascular Diseases Antibodies  >36 publications with PKCA and Cardiovascular Diseases
 Lung Neoplasms Antibodies  >23 publications with PKCA and Lung Neoplasms
 Heart Diseases Antibodies  >19 publications with PKCA and Heart Diseases
 Liver Diseases Antibodies  >17 publications with PKCA and Liver Diseases
 Liver Neoplasms Antibodies  >17 publications with PKCA and Liver Neoplasms

Organs/Tissues associated with anti-PKCA antibody

 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >154 publications with PKCA and Blood
 Brain Antibodies  >78 publications with PKCA and Brain
 Intestine Antibodies  >15 publications with PKCA and Intestine
 Reticulum Antibodies  >12 publications with PKCA and Reticulum
 Mammary Gland Antibodies  >5 publications with PKCA and Mammary Gland
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