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PMVK Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS5312574

PMVK is a cytosolic enzyme that catalyzes the conversion of mevalonate-5-phosphate to mevalonate-5-diphosphate. It is mapped to chromosome 1p13-1q22-23 and spans more than 8.4 kb in the human genome. PMVK is a peroxisomal protein which requires the C-terminal… More details

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Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
PMVK, Polyclonal Antibody
Full Product Name
PMVK Antibody
Product Gene Name
Product Synonym Names
Affinity Purified Rabbit Polyclonal PMVK Antibody; Polyclonal PMVK antibody; Anti-PMVK antibody; Phosphomevalonate Kinase antibody
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Form/Format
Lyophilized Form
Purity/Purification
Affinity Chromatography
Preparation and Storage
Store at 4 degree C for short term storage. For long term storage aliquot and store at -20 degree C. Avoid repeated freeze/thaw cycles.
OMIM
607622
3D Structure
ModBase 3D Structure for Q15126
Immunogen
PMVK antibody was raised in Rabbit using a synthetic peptide corresponding to a sequence in the middle region of human PMVK, identical to the related Rabbit sequence, and different from the related rat sequence by one amino acid, as the immunogen

Product Categories/Family for anti-PMVK antibody

Applications Tested/Suitable for anti-PMVK antibody
Western Blot (WB), Immunohistochemistry (IHC) Paraffin

Immunohistochemistry (IHC) of anti-PMVK antibody

Immunohistochemistry of paraffin-embedded section of Rat Skeletal Muscle Tissue
Rabbit Anti-PMVK Polyclonal Antibody – Cat# MBS5312574

Western Blot (WB) of anti-PMVK antibody

Western Blot using Rat Cardiac Muscle Tissue Lysate
Rabbit Anti-PMVK Polyclonal Antibody, Western Blot (WB) – Cat# MBS5312574

Other Notes

Small volumes of anti-PMVK antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for PMVK purchase

MBS5312574 is an antibody targeting PMVK. Also known as PMVK Antibody. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for PMVK. It may not necessarily be applicable to this product.

NCBI GI #
NCBI GeneID
UniProt Primary Accession #
UniProt Related Accession #
GenBank Nucleotide #
NCBI Official Full Name
phosphomevalonate kinase isoform 1
NCBI Official Synonym Full Names
phosphomevalonate kinase
NCBI Official Symbol
PMVK
NCBI Official Synonym Symbols
PMK; PMKA; PMKASE; POROK1; HUMPMKI
UniProt Protein Name
Phosphomevalonate kinase
UniProt Gene Name
PMVK
UniProt Synonym Gene Names
PMKI; PMKase; hPMK
UniProt Entry Name
PMVK_HUMAN
NCBI Protein Information
phosphomevalonate kinase

NCBI Summary for PMVK

This gene encodes a peroxisomal enzyme that is a member of the galactokinase, homoserine kinase, mevalonate kinase, and phosphomevalonate kinase (GHMP) family of ATP-dependent enzymes. The encoded protein catalyzes the conversion of mevalonate 5-phosphate to mevalonate 5-diphosphate, which is the fifth step in the mevalonate pathway of isoprenoid biosynthesis. Mutations in this gene are linked to certain types of porokeratosis including disseminated superficial porokeratosis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2017]
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UniProt Comments for PMVK

PMVK: Induced by sterol. Monomer.

Protein type: Kinase, other; EC 2.7.4.2; Secondary Metabolites Metabolism - terpenoid backbone biosynthesis

Chromosomal Location of Human Ortholog: 1q22

Cellular Component: membrane; peroxisome; cytosol

Molecular Function: phosphomevalonate kinase activity; ATP binding

Biological Process: isopentenyl diphosphate biosynthetic process, mevalonate pathway; sterol biosynthetic process; phosphorylation; cholesterol biosynthetic process
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Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Organs/Tissues associated with anti-PMVK antibody

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