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Beta Catenin (CTNNB) Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS5313645

beta Catenin is a key downstream component of the canonical Wnt signaling pathway. In the absence of Wnt, forms a complex with AXIN1, AXIN2, APC, CSNK1A1 and GSK3B that promotes phosphorylation on N-terminal Ser and Thr residues and ubiquitination of CTNNB1… More details

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Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Product Overview

Online Datasheet in PDF
Product Name
beta Catenin (CTNNB), Polyclonal Antibody
Full Product Name
beta Catenin Antibody (Ser37)
Product Gene Name
Product Synonym Names
Rabbit Polyclonal beta Catenin Antibody (Ser37); Polyclonal beta Catenin antibody; Anti-beta Catenin antibody; Catenin beta-1 antibody; CTNB1 antibody; CTNNB antibody; CTNNB1 antibody; DKFZp686D02253 antibody; FLJ25606 antibody; FLJ37923 antibody; Beta-catenin antibody; catenin (cadherin-associated protein) beta 1 88kDa antibody
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Form/Format
Supplied in PBS buffer (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% Sodium Azide and 50% Glycerol
Purity/Purification
Affinity Chromatography
Concentration
1 mg/ml (lot specific)
Specificity
beta Catenin antibody (Ser37) detects endogenous levels of beta Catenin only when phosphorylated at serine 37
Preparation and Storage
Store at -20 degree C in small aliquots. Avoid repeat freeze/thaw cycles.
Immunogen
beta Catenin antibody was raised in Rabbit using a synthesized phosphopeptide derived from human beta Catenin around the phosphorylation site of serine 37 (I-H-SP-G-A) as the immunogen.
Cross-Reactivity
Mouse, Rat

Product Categories/Family for anti-CTNNB antibody

Applications Tested/Suitable for anti-CTNNB antibody
Western Blot (WB), Immunohistochemistry (IHC)
Application Notes for anti-CTNNB antibody
WB: 1:500-1:1000
IHC: 1:50-1:100

Immunohistochemistry (IHC) of anti-CTNNB antibody

Immunohistochemical analysis of paraffin-embedded human breast carcinoma tissue using beta Catenin antibody (Ser37)
Rabbit Anti-CTNNB Polyclonal Antibody – Cat# MBS5313645

Western Blot (WB) of anti-CTNNB antibody

Western blot analysis of extract from SW 626 cells, using beta-Catenin antibody and beta Catenin antibody (Ser37) (Lanes 3 and 4)
Rabbit Anti-CTNNB Polyclonal Antibody, Western Blot (WB) – Cat# MBS5313645

Other Notes

Small volumes of anti-CTNNB antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for CTNNB purchase

MBS5313645 is an antibody targeting CTNNB. Also known as beta Catenin Antibody (Ser37). Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for CTNNB. It may not necessarily be applicable to this product.

NCBI GI #
NCBI GeneID
UniProt Related Accession #
NCBI Official Full Name
beta catenin
NCBI Official Synonym Full Names
catenin beta 1
NCBI Official Symbol
CTNNB1
NCBI Official Synonym Symbols
EVR7; CTNNB; MRD19; NEDSDV; armadillo
NCBI Protein Information
catenin beta-1

NCBI Summary for CTNNB

The protein encoded by this gene is part of a complex of proteins that constitute adherens junctions (AJs). AJs are necessary for the creation and maintenance of epithelial cell layers by regulating cell growth and adhesion between cells. The encoded protein also anchors the actin cytoskeleton and may be responsible for transmitting the contact inhibition signal that causes cells to stop dividing once the epithelial sheet is complete. Finally, this protein binds to the product of the APC gene, which is mutated in adenomatous polyposis of the colon. Mutations in this gene are a cause of colorectal cancer (CRC), pilomatrixoma (PTR), medulloblastoma (MDB), and ovarian cancer. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2016]
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Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

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