ARNTL Antibody – Mouse Monoclonal

The protein encoded by this gene is a basic helix-loop-helix protein that forms a heterodimer with CLOCK. This heterodimer binds E-box enhancer elements upstream of Period (PER1, PER2, PER3) and Cryptochrome (CRY1, CRY2) genes and activates transcription of these genes. PER and CRY proteins heterodimerize and repress their own transcription by interacting in a feedback loop with CLOCK/ARNTL complexes. Defects in this gene have been linked to infertility, problems with gluconeogenesis and lipogenesis, and altered sleep patterns. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2014]

BMAL1: aryl hydrocarbon receptor nuclear translocator-like protein. A circadian regulatory protein and substrate of casein kinase I epsilon. Heterodimers bind to an E-box element (3'-CACGTG-5'), thereby activating transcription of PER1, and possibly of other circadian clock proteins. Seven splice isoforms have been reported.

Protein type: DNA-binding; Transcription factor

Chromosomal Location of Human Ortholog: 11p15

Cellular Component: transcription factor complex; PML body; nucleus

Molecular Function: protein binding; signal transducer activity; DNA binding; aryl hydrocarbon receptor binding; protein heterodimerization activity; sequence-specific DNA binding; bHLH transcription factor binding; Hsp90 protein binding

Biological Process: circadian rhythm; transcription from RNA polymerase II promoter; proteasomal ubiquitin-dependent protein catabolic process; negative regulation of TOR signaling pathway; regulation of cell cycle; positive regulation of transcription, DNA-dependent; response to redox state; positive regulation of circadian rhythm; signal transduction; negative regulation of fat cell differentiation; regulation of neurogenesis; regulation of transcription, DNA-dependent; protein import into nucleus, translocation; positive regulation of transcription from RNA polymerase II promoter; regulation of protein catabolic process; spermatogenesis; circadian regulation of gene expression; negative regulation of transcription, DNA-dependent; regulation of hair cycle; regulation of insulin secretion