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BCAR1 Antibody – Mouse Monoclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS532956

MBS532956 is an antibody targeting BCAR1. Also known as BCAR1 antibody. Host: Mouse. Mouse monoclonal BCAR1 antibody More details

$1615 / 0.1 mL +2 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
BCAR1, Monoclonal Antibody
Full Product Name
BCAR1 antibody
Product Gene Name
anti-BCAR1 antibody
Product Synonym Names
Monoclonal BCAR1; Anti-BCAR1; Breast cancer anti-estrogen resistance 1; CAS; CASS1; CRKAS; P130Cas; Cas scaffolding protein family member 1; Crkas; CAS1; p130cas; Breast cancer anti-estrogen resistance protein 1; Crk-associated substrate p130Cas; Crk-associated substrate; BCAR1; BCAR 1; BCAR-1
Clonality
Monoclonal
Isotype
IgG1
Clone Number
3A11
Host
Mouse
Form/Format
Supplied in PBS buffer, pH 7.3, containing 1% BSA, 50% glycerol and 0.02% sodium azide.
Purity/Purification
BCAR1 antibody was purified by affinity chromatography.
Concentration
500 ug-1 mg/ml (lot specific)
Preparation and Storage
Store at 4 degree C for short term storage. Aliquot and store at -20 degree C for long term storage. Avoid repeated freeze/thaw cycles.
Molecular Weight
93,291 Da
OMIM
602941
3D Structure
ModBase 3D Structure for P56945
Cross-Reactivity
Human, Dog, Rat, Monkey, Mouse
Immunogen
BCAR1 antibody was raised in mouse using a full length recombinant protein of human BCAR1 (NP_055382) produced in HEK293T cells, as the immunogen.

Product Categories/Family for anti-BCAR1 antibody

Cell Biology
Applications Tested/Suitable for anti-BCAR1 antibody
Flow Cytometry (FC/FACS), Immunofluorescence (IF), Immunohistochemistry (IHC), Western Blot (WB)
Application Notes for anti-BCAR1 antibody
IF: 1:100
FC: 1:100
IHC: 1:150
WB: 1:500-2000

Western Blot (WB) of anti-BCAR1 antibody

Western Blot analysis of HEK293T cell lysates (5 ug) transfected with either recombinant BCAR1 protein (Right) or empty vector (Left) detected with BCAR1 antibody
Mouse Anti-BCAR1 Monoclonal Antibody – Cat# MBS532956

Immunohistochemistry (IHC) of anti-BCAR1 antibody

Immunohistochemical analysis of BCAR1 protein in paraffin embedded Carcinoma of Human pancreas tissue using BCAR1 antibody
Mouse Anti-BCAR1 Monoclonal Antibody, Immunohistochemistry (IHC) – Cat# MBS532956

Immunofluorescence (IF) of anti-BCAR1 antibody

Immunofluorescent staining of COS7 cells transiently transfected with recombinant BCAR1 protein using BCAR1 antibody
Mouse Anti-BCAR1 Monoclonal Antibody, Immunofluorescence (IF) – Cat# MBS532956

Other Notes

Small volumes of anti-BCAR1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for BCAR1. It may not necessarily be applicable to this product.

NCBI GI #
44662836
NCBI GeneID
9564
NCBI Accession #
NP_055382
UniProt Primary Accession #
P56945
UniProt Secondary Accession #
B3KWD7; B4DEV4; B4DGB5; B4DIW5; B7Z7X7; E9PCL5; E9PCV2; F5GXA2; F5GXV6; F5H7Z0; F8WA69
UniProt Related Accession #
P56945
GenBank Nucleotide #
NM_014567.3
NCBI Official Full Name
breast cancer anti-estrogen resistance protein 1 isoform 6
NCBI Official Synonym Full Names
breast cancer anti-estrogen resistance 1
NCBI Official Symbol
BCAR1
NCBI Official Synonym Symbols
CAS; CAS1; CASS1; CRKAS; P130Cas
UniProt Protein Name
Breast cancer anti-estrogen resistance protein 1
UniProt Synonym Protein Names
CRK-associated substrate; Cas scaffolding protein family member 1; p130cas
Protein Family
Breast cancer anti-estrogen resistance protein
UniProt Gene Name
BCAR1
UniProt Synonym Gene Names
CAS; CASS1; CRKAS
UniProt Entry Name
BCAR1_HUMAN
NCBI Protein Information
breast cancer anti-estrogen resistance protein 1

NCBI Summary for BCAR1

BCAR1, or CAS, is an Src (MIM 190090) family kinase substrate involved in various cellular events, including migration, survival, transformation, and invasion (Sawada et al., 2006 [PubMed 17129785]).[supplied by OMIM, May 2009]

UniProt Comments for BCAR1

P130Cas: a docking protein containing multiple protein-protein interaction domains. Plays a central coordinating role for tyrosine-kinase-based signaling related to cell adhesion. Implicated in induction of cell migration. The amino-terminal SH3 domain regulates its interaction with focal adhesion kinase (FAK) and the FAK-related kinase PYK2 and also with tyrosine phosphatases PTP-1B and PTP-PEST. Overexpression confers antiestrogen resistance on breast cancer cells.

Protein type: Adaptor/scaffold; Motility/polarity/chemotaxis

Chromosomal Location of Human Ortholog: 16q23.1

Cellular Component: ruffle; focal adhesion; lamellipodium; cytoplasm; nucleolus; plasma membrane; cytosol; actin cytoskeleton

Molecular Function: signal transducer activity; protein binding; protein kinase binding; SH3 domain binding

Biological Process: integrin-mediated signaling pathway; epidermal growth factor receptor signaling pathway; antigen receptor-mediated signaling pathway; platelet activation; cell migration; nerve growth factor receptor signaling pathway; actin filament organization; platelet-derived growth factor receptor signaling pathway; hepatocyte growth factor receptor signaling pathway; T cell receptor signaling pathway; regulation of apoptosis; G-protein coupled receptor protein signaling pathway; cell proliferation; B cell receptor signaling pathway; cell division; insulin receptor signaling pathway; regulation of cell growth; vascular endothelial growth factor receptor signaling pathway; cell adhesion; blood coagulation; positive regulation of cell migration
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Research Articles on BCAR1

1. Data introduce hitherto unappreciated paradigms whereby reactive oxygen species can reciprocally regulate the cellular localization of pro- and anti-migratory signaling molecules, p130cas and PTEN, respectively.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-BCAR1 antibody

 Reference Product  PubMed Publications
 CRK antibody  >403 publications with BCAR1 and CRK
 SRC antibody  >169 publications with BCAR1 and SRC
 PTK2 antibody  >106 publications with BCAR1 and PTK2
 PXN antibody  >69 publications with BCAR1 and PXN
 FYN antibody  >14 publications with BCAR1 and FYN
 PTK2B antibody  >12 publications with BCAR1 and PTK2B
 CRKL antibody  >9 publications with BCAR1 and CRKL
 DOCK1 antibody  >5 publications with BCAR1 and DOCK1
 PTPN1 antibody  >4 publications with BCAR1 and PTPN1

Pathways associated with anti-BCAR1 antibody

 Products by Pathway  Pathway Diagram
 B Cell Receptor Signaling Pathway antibodies  B Cell Receptor Signaling Pathway Diagram
 Bacterial Invasion Of Epithelial Cells Pathway antibodies  Bacterial Invasion Of Epithelial Cells Pathway Diagram
 Bacterial Invasion Of Epithelial Cells Pathway antibodies  Bacterial Invasion Of Epithelial Cells Pathway Diagram
 CDC42 Signaling Events Pathway antibodies  CDC42 Signaling Events Pathway Diagram
 CXCR4-mediated Signaling Events Pathway antibodies  CXCR4-mediated Signaling Events Pathway Diagram
 Chemokine Signaling Pathway antibodies  Chemokine Signaling Pathway Diagram
 Chemokine Signaling Pathway antibodies  Chemokine Signaling Pathway Diagram
 Downstream Signal Transduction Pathway antibodies  Downstream Signal Transduction Pathway Diagram
 EGFR1 Signaling Pathway antibodies  EGFR1 Signaling Pathway Diagram
 EPHA2 Forward Signaling Pathway antibodies  EPHA2 Forward Signaling Pathway Diagram

Diseases associated with anti-BCAR1 antibody

 Disease Name  Pubmed Publications
 Breast Neoplasms Antibodies  >49 publications with BCAR1 and Breast Neoplasms
 Cell Transformation, Neoplastic Antibodies  >34 publications with BCAR1 and Cell Transformation, Neoplastic
 Neoplasm Invasiveness Antibodies  >28 publications with BCAR1 and Neoplasm Invasiveness
 Neoplasm Metastasis Antibodies  >20 publications with BCAR1 and Neoplasm Metastasis
 Neoplasms, Experimental Antibodies  >15 publications with BCAR1 and Neoplasms, Experimental
 Lung Diseases Antibodies  >14 publications with BCAR1 and Lung Diseases
 Inflammation Antibodies  >9 publications with BCAR1 and Inflammation
 Cardiovascular Diseases Antibodies  >6 publications with BCAR1 and Cardiovascular Diseases
 Kidney Diseases Antibodies  >5 publications with BCAR1 and Kidney Diseases
 Liver Diseases Antibodies  >4 publications with BCAR1 and Liver Diseases

Organs/Tissues associated with anti-BCAR1 antibody

 Organ/Tissue Name  Pubmed Publications
 Vascular Antibodies  >40 publications with BCAR1 and Vascular
 Muscle Antibodies  >24 publications with BCAR1 and Muscle
 Lung Antibodies  >23 publications with BCAR1 and Lung
 Bone Antibodies  >18 publications with BCAR1 and Bone
 Kidney Antibodies  >14 publications with BCAR1 and Kidney
 Heart Antibodies  >13 publications with BCAR1 and Heart
 Brain Antibodies  >13 publications with BCAR1 and Brain
 Prostate Antibodies  >11 publications with BCAR1 and Prostate
 Pancreas Antibodies  >10 publications with BCAR1 and Pancreas
 Liver Antibodies  >7 publications with BCAR1 and Liver
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