HSPA6 Antibody – Mouse Monoclonal

HSPA6: In cooperation with other chaperones, Hsp70s stabilize preexistent proteins against aggregation and mediate the folding of newly translated polypeptides in the cytosol as well as within organelles. These chaperones participate in all these processes through their ability to recognize nonnative conformations of other proteins. They bind extended peptide segments with a net hydrophobic character exposed by polypeptides during translation and membrane translocation, or following stress-induced damage. Belongs to the heat shock protein 70 family.

Protein type: Heat shock protein

Chromosomal Location of Human Ortholog: 1q23

Cellular Component: centriole; signalosome; cytoplasm; cytosol

Molecular Function: enzyme binding; heat shock protein binding; unfolded protein binding; ATPase activity, coupled; ATP binding

Biological Process: protein refolding; response to unfolded protein