SRC Antibody – Mouse Monoclonal

Src: proto-oncogenic cytoplasmic tyrosine kinase of the SRC family. Highly expressed in certain fully differentiated cells such as neurons, platelets and macrophages. Phosphorylation of an activation loop tyrosine activates the enzyme; phosphorylation of a tyrosine in the C-terminus by Csk inhibits the enzyme. Two alternatively spliced isoforms have been described.

Protein type: Protein kinase, TK; Oncoprotein; Kinase, protein; Protein kinase, tyrosine (non-receptor); EC 2.7.10.2; TK group; Src family

Cellular Component: extrinsic to internal side of plasma membrane; cytoskeleton; mitochondrion; membrane; perinuclear region of cytoplasm; cytoplasm; mitochondrial inner membrane; plasma membrane; actin filament; caveola; intracellular; nucleus

Molecular Function: transferase activity; protein domain specific binding; protein binding; ephrin receptor binding; protein-tyrosine kinase activity; transferase activity, transferring phosphorus-containing groups; nucleotide binding; non-membrane spanning protein tyrosine kinase activity; kinase activity; ATP binding; hormone receptor binding; protein kinase activity

Biological Process: epidermal growth factor receptor signaling pathway; oogenesis; regulation of estrogen receptor signaling pathway; cell migration; peptidyl-tyrosine phosphorylation; progesterone receptor signaling pathway; immune system process; regulation of cell cycle; platelet-derived growth factor receptor signaling pathway; cell cycle; uterus development; protein amino acid phosphorylation; regulation of cell proliferation; regulation of protein binding; forebrain development; innate immune response; cell adhesion; phosphorylation; bone resorption