ATP5B Antibody – Mouse Monoclonal

This gene encodes a subunit of mitochondrial ATP synthase. Mitochondrial ATP synthase catalyzes ATP synthesis, utilizing an electrochemical gradient of protons across the inner membrane during oxidative phosphorylation. ATP synthase is composed of two linked multi-subunit complexes: the soluble catalytic core, F1, and the membrane-spanning component, Fo, comprising the proton channel. The catalytic portion of mitochondrial ATP synthase consists of 5 different subunits (alpha, beta, gamma, delta, and epsilon) assembled with a stoichiometry of 3 alpha, 3 beta, and a single representative of the other 3. The proton channel consists of three main subunits (a, b, c). This gene encodes the beta subunit of the catalytic core. [provided by RefSeq, Jul 2008]

ATP5B: Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core, and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Subunits alpha and beta form the catalytic core in F(1). Rotation of the central stalk against the surrounding alpha(3)beta(3) subunits leads to hydrolysis of ATP in three separate catalytic sites on the beta subunits. Belongs to the ATPase alpha/beta chains family.

Protein type: Mitochondrial; Hydrolase; EC 3.6.3.14; Energy Metabolism - oxidative phosphorylation

Chromosomal Location of Human Ortholog: 12q13.13

Cellular Component: mitochondrial proton-transporting ATP synthase, catalytic core; cell surface; mitochondrion; membrane; mitochondrial matrix; mitochondrial membrane; plasma membrane; nucleus; mitochondrial proton-transporting ATP synthase complex

Molecular Function: protein binding; transporter activity; MHC class I protein binding; ATPase activity; hydrogen ion transporting ATP synthase activity, rotational mechanism; transmembrane transporter activity; hydrogen ion transporting ATPase activity, rotational mechanism; ATP binding

Biological Process: mitochondrion organization and biogenesis; generation of precursor metabolites and energy; substrate-bound cell migration, cell release from substrate; organelle organization and biogenesis; osteoblast differentiation; cellular metabolic process; proton transport; ATP biosynthetic process; regulation of intracellular pH; ATP hydrolysis coupled proton transport; mitochondrial ATP synthesis coupled proton transport; angiogenesis; lipid metabolic process