THRA Antibody – Rabbit Polyclonal

TR-alpha: nuclear hormone receptor and transcription factor. High affinity receptor for triiodothyronine. Interacts with SRC-3 and NCOA6 coactivators, leading to a strong increase of transcription of target genes. Four splice variant isoforms have been described.

Protein type: DNA-binding; Transcription factor; Nuclear receptor

Cellular Component: mitochondrion; cytoplasm; cytosol; nucleus

Molecular Function: RNA polymerase II transcription factor activity, enhancer binding; protein dimerization activity; protein domain specific binding; ligand-dependent nuclear receptor activity; protein homodimerization activity; zinc ion binding; chromatin DNA binding; transcription factor binding; single-stranded RNA binding; DNA binding; TATA-binding protein binding; sequence-specific DNA binding; protein heterodimerization activity; protein complex binding; steroid hormone receptor activity; thyroid hormone receptor activity; transcription factor activity

Biological Process: transcription from RNA polymerase II promoter; hormone-mediated signaling; positive regulation of female receptivity; regulation of myeloid cell apoptosis; regulation of heart contraction; learning and/or memory; thyroid gland development; erythrocyte differentiation; kidney development; cartilage condensation; response to drug; response to nutrient levels; negative regulation of transcriptional preinitiation complex assembly; ossification; cytoplasmic sequestering of transcription factor; intracellular receptor-mediated signaling pathway; adrenal gland development; negative regulation of transcription factor activity; liver development; regulation of lipid catabolic process; regulation of transcription from RNA polymerase II promoter; organ morphogenesis; female courtship behavior; gut development; embryonic organ development; steroid hormone mediated signaling; positive regulation of transcription from RNA polymerase II promoter; response to cold; brain development; negative regulation of transcription, DNA-dependent; lung development