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PLA2G3 Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS535667

MBS535667 is an antibody targeting PLA2G3. Also known as PLA2G3 antibody. Reactive in Human. Host: Rabbit. Rabbit polyclonal PLA2G3 antibody More details

$1660 / 0.05 mg +2 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
PLA2G3, Polyclonal Antibody
Full Product Name
PLA2G3 antibody
Product Gene Name
anti-PLA2G3 antibody
Product Synonym Names
Polyclonal PLA2G3; Anti-PLA2G3; PLAG3 -2; Group III Secreted Phospholipase A2; PLA2G3; PLAG3 2; GIII-SPLA2
Clonality
Polyclonal
Host
Rabbit
Species Reactivity
Human
Form/Format
Purified by Immunoaffinity Chromatography and supplied in PBS with 0.1% NaN3.
Purity/Purification
PLA2G3 antibody was purified by affinity chromatography.
Concentration
1.0 mg/ml (lot specific)
Specificity
Human
Preparation and Storage
Store at 4 degree C for short term storage. Aliquot and store at -70 degree C for long term storage. Avoid repeated freeze/thaw cycles.
Molecular Weight
57,167 Da
OMIM
611651
3D Structure
ModBase 3D Structure for Q9NZ20
Biohazard Information
This product contains sodium azide as preservative. Although the amount of sodium azide is very small appropriate care must be taken when handling.
Immunogen
PLA2G3 antibody was raised in rabbit using a synthetic peptide conjugated to KLH as the immunogen.

Product Categories/Family for anti-PLA2G3 antibody

Proteases; Inhibitors; & Enzymes
Applications Tested/Suitable for anti-PLA2G3 antibody
Immunohistochemistry (IHC) Paraffin
Application Notes for anti-PLA2G3 antibody
IHC-P: 10 ug/ml

Other Notes

Small volumes of anti-PLA2G3 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for PLA2G3. It may not necessarily be applicable to this product.

NCBI GI #
142976884
NCBI GeneID
50487
NCBI Accession #
NP_056530.2
UniProt Primary Accession #
Q9NZ20
UniProt Secondary Accession #
O95768
UniProt Related Accession #
Q9NZ20
GenBank Nucleotide #
NM_015715.3
NCBI Official Full Name
group 3 secretory phospholipase A2
NCBI Official Synonym Full Names
phospholipase A2, group III
NCBI Official Symbol
PLA2G3
NCBI Official Synonym Symbols
SPLA2III; sPLA2-III; GIII-SPLA2
UniProt Protein Name
Group 3 secretory phospholipase A2
UniProt Synonym Protein Names
Group III secretory phospholipase A2; GIII sPLA2; sPLA2-III; Phosphatidylcholine 2-acylhydrolase 3
Protein Family
Group 3 secretory phospholipase
UniProt Gene Name
PLA2G3
UniProt Synonym Gene Names
GIII sPLA2; sPLA2-III
UniProt Entry Name
PA2G3_HUMAN
NCBI Protein Information
group 3 secretory phospholipase A2

NCBI Summary for PLA2G3

This gene encodes a protein that belongs to the secreted phospholipase A2 family, whose members include the bee venom enzyme. The encoded enzyme functions in lipid metabolism and catalyzes the calcium-dependent hydrolysis of the sn-2 acyl bond of phospholipids to release arachidonic acid and lysophospholipids. This enzyme acts as a negative regulator of ciliogenesis, and may play a role in cancer development by stimulating tumor cell growth and angiogenesis. This gene is associated with oxidative stress, and polymorphisms in this gene are linked to risk for Alzheimer's disease. [provided by RefSeq, Apr 2014]
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UniProt Comments for PLA2G3

PLA2G3: PA2 catalyzes the calcium-dependent hydrolysis of the 2- acyl groups in 3-sn-phosphoglycerides. Shows an 11-fold preference for phosphatidylglycerol over phosphatidylcholine (PC). Preferential cleavage: 1-palmitoyl-2-linoleoyl- phosphatidylethanolamine (PE) > 1-palmitoyl-2-linoleoyl-PC > 1- palmitoyl-2-arachidonoyl-PC > 1-palmitoyl-2-arachidonoyl-PE. Plays a role in ciliogenesis. Belongs to the phospholipase A2 family.

Protein type: Lipid Metabolism - ether lipid; EC 3.1.1.4; Lipid Metabolism - linoleic acid; Phospholipase; Lipid Metabolism - glycerophospholipid; Lipid Metabolism - arachidonic acid; Lipid Metabolism - alpha-linolenic acid

Chromosomal Location of Human Ortholog: 22q12.2

Cellular Component: centriole; extracellular space; mast cell granule; extracellular region; plasma membrane

Molecular Function: calcium-dependent phospholipase A2 activity; calcium ion binding

Biological Process: acrosome formation; lipoxygenase pathway; phospholipid metabolic process; glycerophospholipid biosynthetic process; sperm axoneme assembly; mast cell degranulation; lipid catabolic process
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Research Articles on PLA2G3

1. Data indicate that the expression of genes encoding hGIIA, hGIII and hGX sPLA2s (PLA2G2A, PLA2G3 and PLA2G10, respectively) in breast tumour biopsies differs from that in normal tissues.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-PLA2G3 antibody

 Reference Product  PubMed Publications
 PLA2G15 antibody  >1 publications with PLA2G3 and PLA2G15
 PLA2G7 antibody  >1 publications with PLA2G3 and PLA2G7
 PTGS2 antibody  >1 publications with PLA2G3 and PTGS2

Pathways associated with anti-PLA2G3 antibody

 Products by Pathway  Pathway Diagram
 Acyl Chain Remodelling Of PC Pathway antibodies  Acyl Chain Remodelling Of PC Pathway Diagram
 Acyl Chain Remodelling Of PE Pathway antibodies  Acyl Chain Remodelling Of PE Pathway Diagram
 Acyl Chain Remodelling Of PG Pathway antibodies  Acyl Chain Remodelling Of PG Pathway Diagram
 Arachidonic Acid Metabolism Pathway antibodies  Arachidonic Acid Metabolism Pathway Diagram
 Arachidonic Acid Metabolism Pathway antibodies  Arachidonic Acid Metabolism Pathway Diagram
 Ether Lipid Metabolism Pathway antibodies  Ether Lipid Metabolism Pathway Diagram
 Ether Lipid Metabolism Pathway antibodies  Ether Lipid Metabolism Pathway Diagram
 Fat Digestion And Absorption Pathway antibodies  Fat Digestion And Absorption Pathway Diagram
 Fat Digestion And Absorption Pathway antibodies  Fat Digestion And Absorption Pathway Diagram
 Glycerophospholipid Biosynthesis Pathway antibodies  Glycerophospholipid Biosynthesis Pathway Diagram

Diseases associated with anti-PLA2G3 antibody

 Disease Name  Pubmed Publications
 Inflammation Antibodies  >3 publications with PLA2G3 and Inflammation
 Immune System Diseases Antibodies  >2 publications with PLA2G3 and Immune System Diseases
 Nervous System Diseases Antibodies  >2 publications with PLA2G3 and Nervous System Diseases
 Brain Diseases Antibodies  >2 publications with PLA2G3 and Brain Diseases
 Uterine Neoplasms Antibodies  >1 publications with PLA2G3 and Uterine Neoplasms
 Hyperplasia Antibodies  >1 publications with PLA2G3 and Hyperplasia
 Lung Neoplasms Antibodies  >1 publications with PLA2G3 and Lung Neoplasms
 Lung Injury Antibodies  >1 publications with PLA2G3 and Lung Injury
 Necrosis Antibodies  >1 publications with PLA2G3 and Necrosis

Organs/Tissues associated with anti-PLA2G3 antibody

 Organ/Tissue Name  Pubmed Publications
 Intestine Antibodies  >1 publications with PLA2G3 and Intestine
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