ESE1 Antibody – Rabbit Polyclonal

ITSN1: Adapter protein that may provide indirect link between the endocytic membrane traffic and the actin assembly machinery. May regulate the formation of clathrin-coated vesicles. Involved in endocytosis of integrin beta-1 (ITGB1) and transferrin receptor (TFR); internalization of ITGB1 as DAB2-dependent cargo but not TFR may involve association with DAB2. Isoform 1 could be involved in brain-specific synaptic vesicle recycling. Inhibits ARHGAP31 activity toward RAC1. 4 isoforms of the human protein are produced by alternative splicing.

Protein type: Calcium-binding; GEFs; Adaptor/scaffold; GEFs, Rac/Rho

Cellular Component: neuron projection; cell projection; membrane; lamellipodium; endocytic vesicle; plasma membrane; terminal button; synapse; coated pit; cell junction

Molecular Function: protein binding; Rho guanyl-nucleotide exchange factor activity; guanyl-nucleotide exchange factor activity; metal ion binding; kinase activator activity; protein complex scaffold; calcium ion binding

Biological Process: positive regulation of catalytic activity; positive regulation of protein kinase B signaling cascade; small GTPase mediated signal transduction; regulation of Rho protein signal transduction; endocytosis; negative regulation of neuron apoptosis; positive regulation of phosphorylation