VMAT2 Antibody – Rabbit Polyclonal

The vesicular monoamine transporter acts to accumulate cytosolic monoamines into synaptic vesicles, using the proton gradient maintained across the synaptic vesicular membrane. Its proper function is essential to the correct activity of the monoaminergic systems that have been implicated in several human neuropsychiatric disorders. The transporter is a site of action of important drugs, including reserpine and tetrabenazine (summary by Peter et al., 1993 [PubMed 7905859]). See also SLC18A1 (MIM 193002).[supplied by OMIM, Jan 2011]

SLC18A2: Involved in the ATP-dependent vesicular transport of biogenic amine neurotransmitters. Pumps cytosolic monoamines including dopamine, norepinephrine, serotonin, and histamine into synaptic vesicles. Requisite for vesicular amine storage prior to secretion via exocytosis. Belongs to the major facilitator superfamily. Vesicular transporter family.

Protein type: Membrane protein, integral; Transporter; Transporter, SLC family; Membrane protein, multi-pass

Chromosomal Location of Human Ortholog: 10q25

Cellular Component: synaptic vesicle; cell soma; membrane; synaptic vesicle membrane; integral to plasma membrane; plasma membrane; terminal button

Molecular Function: serotonin transmembrane transporter activity; enzyme binding; amine transmembrane transporter activity; heat shock protein binding; monoamine transmembrane transporter activity; drug binding

Biological Process: dopamine transport; amine transport; death; neurotransmitter secretion; monoamine transport; response to amphetamine; locomotory behavior; response to herbicide; response to cocaine; sequestering of neurotransmitter; glucose homeostasis; endocytic recycling; post-embryonic development; response to starvation; synaptic transmission; insulin secretion; response to zinc ion; serotonin transport; transmembrane transport; negative regulation of neurotransmitter transport; response to corticosterone stimulus; aging