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Proteinase-3 (PRTN3) Human Native Protein

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS145450

Description: PRTN3 is a natural antigen having a molecular mass of 25kDa to 32kDa due to glycosylation isoforms. PRTN3 is isolated from human peripheral blood leukocytes.Introduction: PRTN3 is a polymorphonuclear leukocyte serine protease which degrades… More details

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Testing Data View PDF
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Technical Datasheet View PDF
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Product Overview

Online Datasheet in PDF
Product Name
Proteinase-3 (PRTN3), Native Protein
Full Product Name
Human Proteinase-3
Product Gene Name
Product Synonym Names
PRTN3 Human; Proteinase-3 Human; AGP7; P29; PR-3; ACPA; C-ANCA; MBT; MBN; Leukocyte proteinase 3; Neutrophil proteinase 4; Wegener granulomatosis autoantigen; Azurophil granule protein 7; myeloblastin; Serine proteinase neutrophil
Host
Native
Form/Format
PRTN3 is supplied in 16mM HEPES buffer pH-8.0, 400mM NaCl, and 20% glycerol.
Concentration
0.5-1.0 ug/ml (depending on the type of ELISA plate and coating buffer). Suitable for biotinylation and iodination. (lot specific)
Molecular Weight
27,807 Da
OMIM
177020
3D Structure
ModBase 3D Structure for P24158
Immunological Functions
Binds IgG-type human auto-antibodies. Auto-antibodies to PR3 recognize conformation-dependent epitopes.

Product Categories/Family for PRTN3 native protein

Applications Tested/Suitable for PRTN3 native protein
Western Blot (WB), ELISA (EIA), Immunodot
Application Notes for PRTN3 native protein
Western blot with rabbit anti-PR3 antisera and mouse anti-PR3 monoclonal antibodies.
Immunological Tests: Standard ELISA test (checkerboard analysis of positive/negative sera panels); immunodot test.

Other Notes

Small volumes of PRTN3 native protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for PRTN3 purchase

MBS145450 is a native protein targeting PRTN3. Also known as Human Proteinase-3. Host: Native.

Additional Details

NCBI/Uniprot data below describe general gene information for PRTN3. It may not necessarily be applicable to this product.

NCBI GI #
NCBI GeneID
NCBI Accession #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
GenBank Nucleotide #
NCBI Official Full Name
myeloblastin
NCBI Official Synonym Full Names
proteinase 3
NCBI Official Symbol
PRTN3
NCBI Official Synonym Symbols
MBN; MBT; NP4; P29; PR3; ACPA; AGP7; NP-4; PR-3; CANCA; C-ANCA
UniProt Protein Name
Myeloblastin
UniProt Synonym Protein Names
AGP7; C-ANCA antigen; Leukocyte proteinase 3; PR-3; PR3; Neutrophil proteinase 4; NP-4; P29; Wegener autoantigen
Protein Family
UniProt Gene Name
PRTN3
UniProt Synonym Gene Names
MBN; PR-3; PR3; NP-4
UniProt Entry Name
PRTN3_HUMAN
NCBI Protein Information
myeloblastin; C-ANCA antigen; Wegener granulomatosis autoantigen; azurophil granule protein 7; leukocyte proteinase 3; neutrophil proteinase 4; serine proteinase, neutrophil; wegener autoantigen

UniProt Comments for PRTN3

PRTN3: Polymorphonuclear leukocyte serine protease that degrades elastin, fibronectin, laminin, vitronectin, and collagen types I, III, and IV (in vitro) and causes emphysema when administered by tracheal insufflation to hamsters. Belongs to the peptidase S1 family. Elastase subfamily.

Protein type: EC 3.4.21.76; Protease; Cell cycle regulation

Chromosomal Location of Human Ortholog: 19p13.3

Cellular Component: extracellular matrix; extracellular space; plasma membrane; cytosol

Molecular Function: enzyme binding; serine-type peptidase activity; serine-type endopeptidase activity

Biological Process: negative regulation of phagocytosis; collagen catabolic process; positive regulation of cell proliferation; proteolysis; blood coagulation
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Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

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