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GCSF Active Protein

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS538014

MBS538014 is an active protein targeting GCSF. Also known as GCSF protein (Mouse). Host: Mouse. Purified recombinant Mouse GCSF protein More details

$695 / 0.01 mg +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
GCSF, Active Protein
Full Product Name
GCSF protein (Mouse)
Product Gene Name
GCSF active protein
Product Synonym Names
Granulocyte Colony-Stimulating Factor protein; MGI-1G protein; GM-CSFb protein; pluripoietin protein; CSF-3 protein
Sequence
Region of GCSF protein correspond ing to amino acids MVPLVTVSAL PPSLPLPRSF LLKSLEQVRK IQASGSVLLE QLCATYKLCH PEELVLLGHS LGIPKASLSG CSSQALQQTQ CLSQLHSGLC LYQGLLQALS GISPALAPTL DLLQLDVANF ATTIWQQMEN LGVAPTVQPT QSAMPAFTSA FQRRAGGVLA ISYLQGFLET ARLALHHLA.
Host
Mouse
Form/Format
Lyophilized from 5mM sodium citrate, pH 4.0. Reconstitute in water to a concentration of 0.1-1.0 mg/ml.
Purity/Purification
> 98% pure
Preparation and Storage
Store at 4 degree C until reconstitution. Following reconstitution aliquot and freeze at -20 degree C for long term storage. Avoid repeated freeze/thaw cycles.
Molecular Weight
19 kDa
3D Structure
ModBase 3D Structure for P09920
Active Protein Note
Protein activity can be an ambiguous term. Please refer to the data sheet or inquire with Technical Support to determine the definition of activity for this product.
Protein Type
Recombinant
Bioactivity
The ED50 was determined by the dose-dependent stimulation of the proliferation of Mouse M-NFS-60 cells is 2 x 10^7 units/mg.
Endotoxin Levels
Endotoxin level is less than 0.1 ng per ug (1 EU/ug).
Expression System
E Coli

Product Categories/Family for GCSF active protein

Cytokines & Growth Factors
Applications Tested/Suitable for GCSF active protein
User optimized

Other Notes

Small volumes of GCSF active protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for GCSF. It may not necessarily be applicable to this product.

NCBI GI #
6753536
NCBI GeneID
12985
NCBI Accession #
NP_034101.1
UniProt Primary Accession #
P09920
UniProt Related Accession #
P09920
GenBank Nucleotide #
NM_009971.1
NCBI Official Full Name
granulocyte colony-stimulating factor
NCBI Official Synonym Full Names
colony stimulating factor 3 (granulocyte)
NCBI Official Symbol
Csf3
NCBI Official Synonym Symbols
Csfg; G-CSF; MGI-IG
UniProt Protein Name
Granulocyte colony-stimulating factor
UniProt Gene Name
Csf3
UniProt Synonym Gene Names
Csfg; G-CSF
UniProt Entry Name
CSF3_MOUSE
NCBI Protein Information
granulocyte colony-stimulating factor

UniProt Comments for GCSF

G-CSF: Granulocyte/macrophage colony-stimulating factors are cytokines that act in hematopoiesis by controlling the production, differentiation, and function of 2 related white cell populations of the blood, the granulocytes and the monocytes-macrophages. This CSF induces granulocytes. Belongs to the IL-6 superfamily. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Secreted; Cytokine; Secreted, signal peptide; Cell cycle regulation

Cellular Component: extracellular space; extracellular region

Molecular Function: enzyme binding; growth factor activity; cytokine activity

Biological Process: positive regulation of phosphoinositide 3-kinase cascade; positive regulation of protein kinase B signaling cascade; positive regulation of peptidyl-tyrosine phosphorylation; granulocyte differentiation; positive regulation of protein binding; positive regulation of actin filament polymerization; positive regulation of myeloid cell differentiation; positive regulation of cell proliferation; positive regulation of transcription factor import into nucleus; immune response; positive regulation of transcription from RNA polymerase II promoter; positive regulation of peptidyl-serine phosphorylation
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Research Articles on GCSF

1. Exposure of Sca-1(+) cells to G-CSF in the culture medium for 72 h induced time-dependent but self-limiting cell cycle acceleration with a restricted effect on the CSC proliferation.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with GCSF active protein

 Reference Product  PubMed Publications
 Csf2 active protein  >24 publications with GCSF and Csf2
 Csf3r active protein  >15 publications with GCSF and Csf3r
 Il6 active protein  >14 publications with GCSF and Il6
 Lif active protein  >5 publications with GCSF and Lif
 Osm active protein  >2 publications with GCSF and Osm
 Csf2ra active protein  >1 publications with GCSF and Csf2ra
 Il11 active protein  >1 publications with GCSF and Il11
 Cntf active protein  >1 publications with GCSF and Cntf

Pathways associated with GCSF active protein

 Products by Pathway  Pathway Diagram
 Cytokine-cytokine Receptor Interaction Pathway antibodies  Cytokine-cytokine Receptor Interaction Pathway Diagram
 Cytokine-cytokine Receptor Interaction Pathway antibodies  Cytokine-cytokine Receptor Interaction Pathway Diagram
 Cytokines And Inflammatory Response (BioCarta) Pathway antibodies  Cytokines And Inflammatory Response (BioCarta) Pathway Diagram
 Hematopoietic Cell Lineage Pathway antibodies  Hematopoietic Cell Lineage Pathway Diagram
 Hematopoietic Cell Lineage Pathway antibodies  Hematopoietic Cell Lineage Pathway Diagram
 Jak-STAT Signaling Pathway antibodies  Jak-STAT Signaling Pathway Diagram
 Jak-STAT Signaling Pathway antibodies  Jak-STAT Signaling Pathway Diagram
 Malaria Pathway antibodies  Malaria Pathway Diagram
 Malaria Pathway antibodies  Malaria Pathway Diagram
 PI3K-Akt Signaling Pathway antibodies  PI3K-Akt Signaling Pathway Diagram

Diseases associated with GCSF active protein

 Disease Name  Pubmed Publications
 Disease Susceptibility Antibodies  >6 publications with GCSF and Disease Susceptibility
 Nervous System Diseases Antibodies  >5 publications with GCSF and Nervous System Diseases
 Neutropenia Antibodies  >4 publications with GCSF and Neutropenia
 Breast Neoplasms Antibodies  >3 publications with GCSF and Breast Neoplasms
 Neoplasm Metastasis Antibodies  >3 publications with GCSF and Neoplasm Metastasis
 Leukopenia Antibodies  >2 publications with GCSF and Leukopenia
 Anemia Antibodies  >2 publications with GCSF and Anemia
 Leukemia, Myeloid, Acute Antibodies  >2 publications with GCSF and Leukemia, Myeloid, Acute
 Hypertrophy Antibodies  >2 publications with GCSF and Hypertrophy
 Carcinoma Antibodies  >2 publications with GCSF and Carcinoma

Organs/Tissues associated with GCSF active protein

 Organ/Tissue Name  Pubmed Publications
 Lung Antibodies  >5 publications with GCSF and Lung
 Mammary Gland Antibodies  >3 publications with GCSF and Mammary Gland
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