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GRO gamma Active Protein

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS538137

MBS538137 is an active protein targeting GRO gamma. Also known as GRO gamma protein. Host: Human. Purified recombinant Human GRO gamma protein More details

$695 / 0.01 mg +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
GRO gamma, Active Protein
Full Product Name
GRO gamma protein
Product Gene Name
GRO gamma active protein
Product Synonym Names
CXCL3 protein; Growth Regulated Protein/Melanoma Growth Stimulatory Activity protein; MGSA gamma protein; MIP-2 protein; GRO3 protein
Sequence
Region of GRO gamma protein correspond ing to amino acids ASVVTELRCQ CLQTLQGIHL KNIQSVNVRS PGPHCAQTEV IATLKNGKKA CLNPASPMVQ KIIEKILNKG STN.
Host
Human
Form/Format
Supplied lyophilized with no additives. Reconstitute in water to a concentration of 0.1-1.0 mg/ml
Purity/Purification
> 98% pure
Preparation and Storage
Store at 4 degree C until reconstitution. Following reconstitution aliquot and freeze at -20 degree C for long term storage. Avoid repeated freeze/thaw cycles.
Molecular Weight
7.9 kDa
OMIM
139111
Active Protein Note
Protein activity can be an ambiguous term. Please refer to the data sheet or inquire with Technical Support to determine the definition of activity for this product.
Protein Type
Recombinant
Bioactivity
Determined by its ability to chemoattract 293 transfected CXCR2 cells using a concentration range of 10-100 ng/ml.
Endotoxin Levels
Endotoxin level is less than 0.1 ng per ug (1 EU/ug).
Expression System
E Coli

Product Categories/Family for GRO gamma active protein

Cytokines & Growth Factors
Applications Tested/Suitable for GRO gamma active protein
User optimized

Other Notes

Small volumes of GRO gamma active protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for GRO gamma. It may not necessarily be applicable to this product.

NCBI GI #
30023531
NCBI GeneID
2921
NCBI Accession #
AAP13105.1
UniProt Secondary Accession #
Q4W5H9
UniProt Related Accession #
P19876
NCBI Official Full Name
GRO-gamma, partial
NCBI Official Synonym Full Names
chemokine (C-X-C motif) ligand 3
NCBI Official Symbol
CXCL3
NCBI Official Synonym Symbols
GRO3; GROg; MIP2B; SCYB3; MIP-2b; CINC-2b
UniProt Protein Name
C-X-C motif chemokine 3
UniProt Synonym Protein Names
GRO-gamma(1-73); Growth-regulated protein gamma; GRO-gamma
Protein Family
Growth-regulated protein
UniProt Gene Name
CXCL3
UniProt Synonym Gene Names
GRO3; GROG; SCYB3; GRO-gamma; MIP2-beta
UniProt Entry Name
CXCL3_HUMAN
NCBI Protein Information
C-X-C motif chemokine 3

NCBI Summary for GRO gamma

This antimicrobial gene encodes a member of the CXC subfamily of chemokines. The encoded protein is a secreted growth factor that signals through the G-protein coupled receptor, CXC receptor 2. This protein plays a role in inflammation and as a chemoattractant for neutrophils. [provided by RefSeq, Sep 2014]
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UniProt Comments for GRO gamma

CXCL3: Ligand for CXCR2. Has chemotactic activity for neutrophils. May play a role in inflammation and exert its effects on endothelial cells in an autocrine fashion. In vitro, the processed form GRO-gamma(5-73) shows a fivefold higher chemotactic activity for neutrophilic granulocytes. Belongs to the intercrine alpha (chemokine CxC) family.

Protein type: Secreted; Secreted, signal peptide; Motility/polarity/chemotaxis

Chromosomal Location of Human Ortholog: 4q21

Cellular Component: extracellular space; extracellular region

Molecular Function: chemokine activity; CXCR chemokine receptor binding

Biological Process: G-protein coupled receptor protein signaling pathway; neutrophil chemotaxis; response to lipopolysaccharide; immune response; positive regulation of leukocyte chemotaxis; inflammatory response; regulation of cell proliferation
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Research Articles on GRO gamma

1. results support a functional role of CXCL3 in breast cancer metastasis and as a viable target for cancer therapy

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with GRO gamma active protein

 Reference Product  PubMed Publications
 CCL20 active protein  >41 publications with GRO gamma and CCL20
 CCL5 active protein  >26 publications with GRO gamma and CCL5
 CXCL10 active protein  >21 publications with GRO gamma and CXCL10
 CXCL11 active protein  >13 publications with GRO gamma and CXCL11
 CXCR2 active protein  >12 publications with GRO gamma and CXCR2
 CXCR1 active protein  >9 publications with GRO gamma and CXCR1
 CXCL12 active protein  >8 publications with GRO gamma and CXCL12
 CXCL16 active protein  >6 publications with GRO gamma and CXCL16
 CCL19 active protein  >6 publications with GRO gamma and CCL19
 CCR1 active protein  >3 publications with GRO gamma and CCR1

Pathways associated with GRO gamma active protein

 Products by Pathway  Pathway Diagram
 Chemokine Receptors Bind Chemokines Pathway antibodies  Chemokine Receptors Bind Chemokines Pathway Diagram
 Chemokine Signaling Pathway antibodies  Chemokine Signaling Pathway Diagram
 Chemokine Signaling Pathway antibodies  Chemokine Signaling Pathway Diagram
 Class A/1 (Rhodopsin-like Receptors) Pathway antibodies  Class A/1 (Rhodopsin-like Receptors) Pathway Diagram
 Cytokine-cytokine Receptor Interaction Pathway antibodies  Cytokine-cytokine Receptor Interaction Pathway Diagram
 Cytokine-cytokine Receptor Interaction Pathway antibodies  Cytokine-cytokine Receptor Interaction Pathway Diagram
 G Alpha (i) Signalling Events Pathway antibodies  G Alpha (i) Signalling Events Pathway Diagram
 GPCR Downstream Signaling Pathway antibodies  GPCR Downstream Signaling Pathway Diagram
 GPCR Ligand Binding Pathway antibodies  GPCR Ligand Binding Pathway Diagram
 Legionellosis Pathway antibodies  Legionellosis Pathway Diagram

Diseases associated with GRO gamma active protein

 Disease Name  Pubmed Publications
 Inflammation Antibodies  >75 publications with GRO gamma and Inflammation
 Necrosis Antibodies  >36 publications with GRO gamma and Necrosis
 Respiratory Tract Diseases Antibodies  >13 publications with GRO gamma and Respiratory Tract Diseases
 Lung Diseases Antibodies  >13 publications with GRO gamma and Lung Diseases
 Immune System Diseases Antibodies  >11 publications with GRO gamma and Immune System Diseases
 Skin Diseases Antibodies  >9 publications with GRO gamma and Skin Diseases
 Death Antibodies  >7 publications with GRO gamma and Death
 Fibrosis Antibodies  >6 publications with GRO gamma and Fibrosis
 Neoplasms, Experimental Antibodies  >5 publications with GRO gamma and Neoplasms, Experimental
 Lung Neoplasms Antibodies  >4 publications with GRO gamma and Lung Neoplasms

Organs/Tissues associated with GRO gamma active protein

 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >65 publications with GRO gamma and Blood
 Lung Antibodies  >19 publications with GRO gamma and Lung
 Intestine Antibodies  >13 publications with GRO gamma and Intestine
 Brain Antibodies  >8 publications with GRO gamma and Brain
 Embryonic Tissue Antibodies  >4 publications with GRO gamma and Embryonic Tissue
 Liver Antibodies  >4 publications with GRO gamma and Liver
 Uterus Antibodies  >2 publications with GRO gamma and Uterus
 Pancreas Antibodies  >1 publications with GRO gamma and Pancreas
 Bladder Antibodies  >1 publications with GRO gamma and Bladder
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