Oncostatin M (OSM) Active Protein

Name: OSM Active Protein; Oncostatin M; Research Grade; MyBioSource
Brand: MyBioSource
SKU: MBS539546
Price: 685 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS539546

MBS539546 is an active protein targeting OSM. Also known as Oncostatin M protein. Host: Human. Purified recombinant Human Oncostatin M protein More details

$685 / 0.01 mg +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

Oncostatin M (OSM), Active Protein

Full Product Name

Oncostatin M protein

Product Gene Name

OSM active protein

Product Synonym Names

OSM protein

Sequence

Region of Oncostatin M protein correspond ing to amino acids MAAIGSCSKE YRVLLGQLQK QTDLMQDTSR LLDPYIRIQG LDVPKLREHC RERPGAFPSE ETLRGLGRRG FLQTLNATLG CVLHRLADLE QRLPKAQDLE RSGLNIEDLE KLQMARPNIL GLRNNIYCMA QLLDNSDTAE PTKAGRGASQ PPTPTPASDA FQRKLEGCRF LHGYHRFMHS VGRVFSKWGE SPNRSRRHSP HQALRKGVRR .

Host

Human

Form/Format

Supplied as a lyophilized powder.

Purity/Purification

> 98% pure

Preparation and Storage

Store at 4 degree C until reconstitution. Following reconstitution aliquot and freeze at -20 degree C for long term storage. Avoid repeated freeze/thaw cycles.

Molecular Weight

26 kDa

OMIM

165095

3D Structure

ModBase 3D Structure for P13725

Active Protein Note

Protein activity can be an ambiguous term. Please refer to the data sheet or inquire with Technical Support to determine the definition of activity for this product.

Protein Type

Recombinant

Bioactivity

The ED50 was determined by the dose-dependent stimulation of the proliferation of human TF-1 cells is approximately 2.0 ng/ml, corresponding to a specific activity of approximately 5 x 10^5 units/mg.

Endotoxin Levels

Endotoxin level is less than 0.1 ng per ug (1 EU/ug).

Expression System

E Coli

Product Categories/Family for OSM active protein

Cytokines & Growth Factors

Applications Tested/Suitable for OSM active protein

User optimized

Other Notes

Small volumes of OSM active protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for OSM. It may not necessarily be applicable to this product.

NCBI GI #

10092621

NCBI GeneID

5008

NCBI Accession #

NP_065391.1

UniProt Primary Accession #

P13725

UniProt Secondary Accession #

Q6FHP8; Q9UCP6

UniProt Related Accession #

P13725

GenBank Nucleotide #

NM_020530.4

NCBI Official Full Name

oncostatin-M preproprotein

NCBI Official Synonym Full Names

oncostatin M

NCBI Official Symbol

OSM

UniProt Protein Name

Oncostatin-M

Protein Family

Oncostatin

UniProt Gene Name

OSM

UniProt Synonym Gene Names

OSM

UniProt Entry Name

ONCM_HUMAN

NCBI Protein Information

oncostatin-M

NCBI Summary for OSM

Oncostatin M is a member of a cytokine family that includes leukemia-inhibitory factor, granulocyte colony-stimulating factor, and interleukin 6. This gene encodes a growth regulator which inhibits the proliferation of a number of tumor cell lines. It regulates cytokine production, including IL-6, G-CSF and GM-CSF from endothelial cells. [provided by RefSeq, Jul 2008]

UniProt Comments for OSM

OSM: Growth regulator. Inhibits the proliferation of a number of tumor cell lines. Stimulates proliferation of AIDS-KS cells. It regulates cytokine production, including IL-6, G-CSF and GM-CSF from endothelial cells. Uses both type I OSM receptor (heterodimers composed of LIPR and IL6ST) and type II OSM receptor (heterodimers composed of OSMR and IL6ST). Involved in the maturation of fetal hepatocytes, thereby promoting liver development and regeneration. Belongs to the LIF/OSM family.

Protein type: Secreted; Cytokine; Secreted, signal peptide

Chromosomal Location of Human Ortholog: 22q12.2

Cellular Component: extracellular space

Molecular Function: growth factor activity; oncostatin-M receptor binding; cytokine activity

Biological Process: negative regulation of hormone secretion; multicellular organismal development; tyrosine phosphorylation of Stat3 protein; tyrosine phosphorylation of Stat5 protein; positive regulation of peptidyl-serine phosphorylation; peripheral nervous system development; cell proliferation; negative regulation of cell proliferation; positive regulation of peptidyl-tyrosine phosphorylation; behavioral response to pain; positive regulation of MAPKKK cascade; positive regulation of acute inflammatory response; response to heat; positive regulation of cell division; regulation of growth; positive regulation of cell proliferation; negative regulation of meiosis; tyrosine phosphorylation of Stat1 protein; positive regulation of transcription from RNA polymerase II promoter; immune response

Research Articles on OSM

1. OSM promotes STAT3-dependent intestinal epithelial cell proliferation and wound healing in vitro.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with OSM active protein

Reference Product	PubMed Publications
LIFR active protein	>396 publications with OSM and LIFR
STAT3 active protein	>261 publications with OSM and STAT3
CNTF active protein	>185 publications with OSM and CNTF
IL6ST active protein	>178 publications with OSM and IL6ST
IL11 active protein	>81 publications with OSM and IL11
OSMR active protein	>72 publications with OSM and OSMR
JAK2 active protein	>48 publications with OSM and JAK2
IL6 active protein	>28 publications with OSM and IL6
CTF1 active protein	>1 publications with OSM and CTF1
EPOR active protein	>1 publications with OSM and EPOR

Pathways associated with OSM active protein

Products by Pathway	Pathway Diagram
Adipogenesis Pathway antibodies	Adipogenesis Pathway Diagram
Cytokine-cytokine Receptor Interaction Pathway antibodies	Cytokine-cytokine Receptor Interaction Pathway Diagram
Cytokine-cytokine Receptor Interaction Pathway antibodies	Cytokine-cytokine Receptor Interaction Pathway Diagram
Jak-STAT Signaling Pathway antibodies	Jak-STAT Signaling Pathway Diagram
Jak-STAT Signaling Pathway antibodies	Jak-STAT Signaling Pathway Diagram
Oncostatin M Signaling Pathway antibodies	Oncostatin M Signaling Pathway Diagram
PI3K-Akt Signaling Pathway antibodies	PI3K-Akt Signaling Pathway Diagram
PI3K-Akt Signaling Pathway antibodies	PI3K-Akt Signaling Pathway Diagram

Diseases associated with OSM active protein

Disease Name	Pubmed Publications
Inflammation Antibodies	>218 publications with OSM and Inflammation
Necrosis Antibodies	>156 publications with OSM and Necrosis
Vascular Diseases Antibodies	>79 publications with OSM and Vascular Diseases
Disease Models, Animal Antibodies	>71 publications with OSM and Disease Models, Animal
Kidney Diseases Antibodies	>54 publications with OSM and Kidney Diseases
Fibrosis Antibodies	>50 publications with OSM and Fibrosis
Breast Neoplasms Antibodies	>45 publications with OSM and Breast Neoplasms
Liver Neoplasms Antibodies	>44 publications with OSM and Liver Neoplasms
Lung Diseases Antibodies	>40 publications with OSM and Lung Diseases
Neoplasms, Experimental Antibodies	>31 publications with OSM and Neoplasms, Experimental

Organs/Tissues associated with OSM active protein

Organ/Tissue Name	Pubmed Publications
Blood Antibodies	>466 publications with OSM and Blood
Kidney Antibodies	>128 publications with OSM and Kidney
Lung Antibodies	>102 publications with OSM and Lung
Intestine Antibodies	>24 publications with OSM and Intestine
Thymus Antibodies	>17 publications with OSM and Thymus
Ovary Antibodies	>15 publications with OSM and Ovary
Uncharacterized Tissue Antibodies	>2 publications with OSM and Uncharacterized Tissue