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PIGF2 Active Protein

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS539592

MBS539592 is an active protein targeting PIGF2. Also known as PIGF2 protein. Host: Human. Purified recombinant Human PIGF2 protein More details

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Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Product Name
PIGF2, Active Protein
Full Product Name
PIGF2 protein
Product Gene Name
PIGF2 active protein
Product Synonym Names
Placenta Growth Factor-2 protein; PIGF-2; PIGF 2; PIGF 2 protein; PIGF-2 protein; PGFL protein; PIGF2
Sequence
Region of PIGF2 protein correspond ing to amino acids LPAVPPQQWA LSAGNGSSEV EVVPFQEVWG RSYCRALERL VDVVSEYPSE VEHMFSPSCV SLLRCTGCCG DENLHCVPVE TANVTMQLLK IRSGDRPSYV ELTFSQHVRC ECRPLREKMK PERRRPKGRG KRRREKQRPT DCCGDAVPRR .
Host
Human
Form/Format
Supplied as a lyophilized powder.
Purity/Purification
> 95% pure
Preparation and Storage
Store at 4 degree C until reconstitution. Following reconstitution aliquot and freeze at -20 degree C for long term storage. Avoid repeated freeze/thaw cycles.
Molecular Weight
34 kDa
3D Structure
ModBase 3D Structure for Q53XY6
Active Protein Note
Protein activity can be an ambiguous term. Please refer to the data sheet or inquire with Technical Support to determine the definition of activity for this product.
Protein Type
Recombinant
Bioactivity
Determined by its ability to chemoattract human monocytes of using a concentration range of 5.0-50.0 ng/ml.
Endotoxin Levels
Endotoxin level is less than 0.1 ng per ug (1 EU/ug).
Expression System
E Coli

Product Categories/Family for PIGF2 active protein

Cytokines & Growth Factors
Applications Tested/Suitable for PIGF2 active protein
User optimized

Other Notes

Small volumes of PIGF2 active protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for PIGF2. It may not necessarily be applicable to this product.

NCBI GI #
7717236
NCBI GeneID
5228
NCBI Accession #
AAB30462.2
UniProt Primary Accession #
Q53XY6
UniProt Related Accession #
P49763
NCBI Official Full Name
placenta growth factor 2
NCBI Official Synonym Full Names
placental growth factor
NCBI Official Symbol
PGF
NCBI Official Synonym Symbols
PGFL; PLGF; PlGF-2; D12S1900; SHGC-10760
UniProt Protein Name
Placental growth factor
UniProt Synonym Protein Names
Placental growth factor
UniProt Gene Name
PGF
UniProt Entry Name
Q53XY6_HUMAN
NCBI Protein Information
placenta growth factor

NCBI Summary for PIGF2

This gene encodes a growth factor found in placenta which is homologous to vascular endothelial growth factor. Alternatively spliced transcripts encoding different isoforms have been found for this gene.[provided by RefSeq, Jun 2011]

UniProt Comments for PIGF2

PGF: Growth factor active in angiogenesis and endothelial cell growth, stimulating their proliferation and migration. It binds to the receptor FLT1/VEGFR-1. Isoform PlGF-2 binds NRP1/neuropilin-1 and NRP2/neuropilin-2 in a heparin-dependent manner. Also promotes cell tumor growth. Belongs to the PDGF/VEGF growth factor family. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: Secreted, signal peptide; Secreted

Chromosomal Location of Human Ortholog: 14q24.3

Cellular Component: extracellular space; membrane; extracellular region

Molecular Function: heparin binding; protein binding; protein homodimerization activity; growth factor activity; protein heterodimerization activity

Biological Process: response to drug; organ regeneration; female pregnancy; signal transduction; cellular response to hormone stimulus; positive regulation of angiogenesis; cell-cell signaling; ureteric bud branching; positive regulation of cell division; positive regulation of cell proliferation; response to hypoxia; positive regulation of endothelial cell proliferation; sprouting angiogenesis; vascular endothelial growth factor receptor signaling pathway; cell differentiation
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Research Articles on PIGF2

1. Decreased PlGF serum concentration in mid-pregnancy, as well as a lack of physiological increase in PlGF levels between early and mid-gestation, may precede development of small for gestational age newborns in women with type I diabetes mellitus.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with PIGF2 active protein

 Reference Product  PubMed Publications
 VEGFA active protein  >26 publications with PIGF2 and VEGFA
 FLT1 active protein  >21 publications with PIGF2 and FLT1
 KDR active protein  >14 publications with PIGF2 and KDR
 VEGFC active protein  >8 publications with PIGF2 and VEGFC
 VEGFB active protein  >5 publications with PIGF2 and VEGFB
 NRP1 active protein  >5 publications with PIGF2 and NRP1
 TEK active protein  >4 publications with PIGF2 and TEK
 FIGF active protein  >3 publications with PIGF2 and FIGF
 FLT4 active protein  >3 publications with PIGF2 and FLT4
 PIK3CA active protein  >1 publications with PIGF2 and PIK3CA

Pathways associated with PIGF2 active protein

 Products by Pathway  Pathway Diagram
 Focal Adhesion Pathway antibodies  Focal Adhesion Pathway Diagram
 Focal Adhesion Pathway antibodies  Focal Adhesion Pathway Diagram
 Focal Adhesion Pathway antibodies  Focal Adhesion Pathway Diagram
 PI3K-Akt Signaling Pathway antibodies  PI3K-Akt Signaling Pathway Diagram
 PI3K-Akt Signaling Pathway antibodies  PI3K-Akt Signaling Pathway Diagram
 Pathways In Cancer antibodies  Pathways In Cancer Diagram
 Rap1 Signaling Pathway antibodies  Rap1 Signaling Pathway Diagram
 Rap1 Signaling Pathway antibodies  Rap1 Signaling Pathway Diagram
 Ras Signaling Pathway antibodies  Ras Signaling Pathway Diagram
 Signal Transduction Pathway antibodies  Signal Transduction Pathway Diagram

Diseases associated with PIGF2 active protein

 Disease Name  Pubmed Publications
 Cardiovascular Diseases Antibodies  >395 publications with PIGF2 and Cardiovascular Diseases
 Inflammation Antibodies  >293 publications with PIGF2 and Inflammation
 Hypertension Antibodies  >198 publications with PIGF2 and Hypertension
 Disease Models, Animal Antibodies  >161 publications with PIGF2 and Disease Models, Animal
 Necrosis Antibodies  >158 publications with PIGF2 and Necrosis
 Heart Diseases Antibodies  >132 publications with PIGF2 and Heart Diseases
 Lung Diseases Antibodies  >130 publications with PIGF2 and Lung Diseases
 Atherosclerosis Antibodies  >93 publications with PIGF2 and Atherosclerosis
 Brain Diseases Antibodies  >73 publications with PIGF2 and Brain Diseases
 Kidney Diseases Antibodies  >71 publications with PIGF2 and Kidney Diseases

Organs/Tissues associated with PIGF2 active protein

 Organ/Tissue Name  Pubmed Publications
 Ovary Antibodies  >774 publications with PIGF2 and Ovary
 Uterus Antibodies  >733 publications with PIGF2 and Uterus
 Muscle Antibodies  >508 publications with PIGF2 and Muscle
 Heart Antibodies  >253 publications with PIGF2 and Heart
 Lung Antibodies  >241 publications with PIGF2 and Lung
 Kidney Antibodies  >215 publications with PIGF2 and Kidney
 Placenta Antibodies  >214 publications with PIGF2 and Placenta
 Embryonic Tissue Antibodies  >200 publications with PIGF2 and Embryonic Tissue
 Brain Antibodies  >196 publications with PIGF2 and Brain
 Liver Antibodies  >139 publications with PIGF2 and Liver
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