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sDLL1 Active Protein

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS539606

MBS539606 is an active protein targeting sDLL1. Also known as sDLL1 protein. Host: Human. Purified recombinant Human sDLL1 protein More details

$685 / 0.025 mg +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
sDLL1, Active Protein
Full Product Name
sDLL1 protein
Product Gene Name
sDLL1 active protein
Product Synonym Names
sDLL-1 protein; Delta-like protein 1 protein; Delta-1 protein; sDLL1; sDLL 1 protein; sDLL 1; sDLL-1
Sequence
Region of SDLL1 protein correspond ing to amino acids SGVFELKLQE FVNKKGLLGN RNCCRGGAGP PPCACRTFFR VCLKHYQASV SPEPPCTYGS AVTPVLGVDS FSLPDGGGAD SAFSNPIRFP FGFTWPGTFS LIIEALHTDS PDDLATENPE RLISRLATQR HLTVGEEWSQ DLHSSGRTDL KYSYRFVCDE HYYGEGCSVF CRPRDDAFGH FTCGERGEKV CNPGWKGPYC TEPICLPGCD EQHGFCDKPG ECKCRVGWQG RYCDECIRYP GCLHGTCQQP WQCNCQEGWG GLFCNQDLNY CTHHKPCKNG ATCTNTGQGS YTCSCRPGYT GATCELGIDE CDPSPCKNGG SCTDLENSYS CTCPPGFYGK ICELSAMTCA DGPCFNGGRC SDSPDGGYSC RCPVGYSGFN CEKKIDYCSS SPCSNGAKCV DLGDAYLCRC QAGFSGRHCD DNVDDCASSP CANGGTCRDG VNDFSCTCPP GYTGRNCSAP VSRCEHAPCH NGATCHERGH RYVCECARGY GGPNCQFLLP ELPPGPAVVD LTEKLEGQGG PF.
Host
Human
Form/Format
Lyophilized from PBS, pH 7.5,
Purity/Purification
> 95% pure
Preparation and Storage
Store at 4 degree C until reconstitution. Following reconstitution aliquot and freeze at -20 degree C for long term storage. Avoid repeated freeze/thaw cycles.
Molecular Weight
57-60 kDa
OMIM
606582
3D Structure
ModBase 3D Structure for O00548
Active Protein Note
Protein activity can be an ambiguous term. Please refer to the data sheet or inquire with Technical Support to determine the definition of activity for this product.
Protein Type
Recombinant
Bioactivity
Determined by the dose dependent growth suppression of the human acute mon degree Cytic leukemia cell line, THP-1. sDLL-1 inhibits the proliferation in THP-1 cells using a concentration of 3.0-5.0 ug/ml.
Endotoxin Levels
Endotoxin level is less than 0.1 ng per ug (1 EU/ug).
Expression System
293 cells

Product Categories/Family for sDLL1 active protein

Cytokines & Growth Factors
Applications Tested/Suitable for sDLL1 active protein
User optimized

Other Notes

Small volumes of sDLL1 active protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for sDLL1. It may not necessarily be applicable to this product.

NCBI GI #
110735443
NCBI GeneID
28514
NCBI Accession #
NP_005609.3
UniProt Primary Accession #
O00548
UniProt Secondary Accession #
Q9NU41; Q9UJV2; B2RAK7; B5M0B3
UniProt Related Accession #
O00548
GenBank Nucleotide #
NM_005618.3
NCBI Official Full Name
delta-like protein 1
NCBI Official Synonym Full Names
delta-like 1 (Drosophila)
NCBI Official Symbol
DLL1
NCBI Official Synonym Symbols
DL1; Delta; DELTA1
UniProt Protein Name
Delta-like protein 1
UniProt Synonym Protein Names
Drosophila Delta homolog 1; Delta1; H-Delta-1
UniProt Gene Name
DLL1
UniProt Synonym Gene Names
Delta1; H-Delta-1
UniProt Entry Name
DLL1_HUMAN
NCBI Protein Information
delta-like protein 1

NCBI Summary for sDLL1

DLL1 is a human homolog of the Notch Delta ligand and is a member of the delta/serrate/jagged family. It plays a role in mediating cell fate decisions during hematopoiesis. It may play a role in cell-to-cell communication. [provided by RefSeq, Jul 2008]

UniProt Comments for sDLL1

DLL1: Acts as a ligand for Notch receptors. Blocks the differentiation of progenitor cells into the B-cell lineage while promoting the emergence of a population of cells with the characteristics of a T-cell/NK-cell precursor. Interacts with Notch receptors. Expressed in heart and pancreas, with lower expression in brain and muscle and almost no expression in placenta, lung, liver and kidney.

Protein type: Cell development/differentiation; Motility/polarity/chemotaxis; Membrane protein, integral

Chromosomal Location of Human Ortholog: 6q27

Cellular Component: integral to plasma membrane; plasma membrane; extracellular region; cytoplasmic vesicle

Molecular Function: protein binding; calcium ion binding; Notch binding

Biological Process: regulation of cell adhesion; Notch signaling pathway; negative regulation of myeloid cell differentiation; negative regulation of interleukin-10 production; Notch receptor processing; cell fate determination; compartment specification; somite specification; cell-cell signaling; negative regulation of auditory receptor cell differentiation; positive regulation of transcription from RNA polymerase II promoter; hemopoiesis; heart looping; cell differentiation; determination of left/right symmetry; inner ear development; positive regulation of Notch signaling pathway
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Research Articles on sDLL1

1. Delta-like 1-mediated Notch signaling enhances the in vitro conversion of human memory CD4 T cells into FOXP3-expressing regulatory T cells.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with sDLL1 active protein

 Reference Product  PubMed Publications
 NOTCH1 active protein  >115 publications with sDLL1 and NOTCH1
 NOTCH3 active protein  >19 publications with sDLL1 and NOTCH3
 NOTCH4 active protein  >15 publications with sDLL1 and NOTCH4
 MIB1 active protein  >5 publications with sDLL1 and MIB1
 PSEN1 active protein  >3 publications with sDLL1 and PSEN1
 ADAM10 active protein  >3 publications with sDLL1 and ADAM10
 ADAM12 active protein  >2 publications with sDLL1 and ADAM12

Pathways associated with sDLL1 active protein

 Products by Pathway  Pathway Diagram
 Activated NOTCH1 Transmits Signal To The Nucleus Pathway antibodies  Activated NOTCH1 Transmits Signal To The Nucleus Pathway Diagram
 Constitutive Signaling By NOTCH1 HD Domain Mutants Pathway antibodies  Constitutive Signaling By NOTCH1 HD Domain Mutants Pathway Diagram
 Constitutive Signaling By NOTCH1 HD+PEST Domain Mutants Pathway antibodies  Constitutive Signaling By NOTCH1 HD+PEST Domain Mutants Pathway Diagram
 Constitutive Signaling By NOTCH1 PEST Domain Mutants Pathway antibodies  Constitutive Signaling By NOTCH1 PEST Domain Mutants Pathway Diagram
 Constitutive Signaling By NOTCH1 T(7;9)(NOTCH1:M1580_K2555) Translocation Mutant Pathway antibodies  Constitutive Signaling By NOTCH1 T(7;9)(NOTCH1:M1580_K2555) Translocation Mutant Pathway Diagram
 Delta-Notch Signaling Pathway antibodies  Delta-Notch Signaling Pathway Diagram
 Disease Pathway antibodies  Disease Pathway Diagram
 Diseases Of Signal Transduction Pathway antibodies  Diseases Of Signal Transduction Pathway Diagram
 NOTCH2 Activation And Transmission Of Signal To The Nucleus Pathway antibodies  NOTCH2 Activation And Transmission Of Signal To The Nucleus Pathway Diagram
 Neural Crest Differentiation Pathway antibodies  Neural Crest Differentiation Pathway Diagram

Diseases associated with sDLL1 active protein

 Disease Name  Pubmed Publications
 Congenital Abnormalities Antibodies  >11 publications with sDLL1 and Congenital Abnormalities
 Immune System Diseases Antibodies  >11 publications with sDLL1 and Immune System Diseases
 Disease Models, Animal Antibodies  >11 publications with sDLL1 and Disease Models, Animal
 Inflammation Antibodies  >10 publications with sDLL1 and Inflammation
 Carcinoma Antibodies  >10 publications with sDLL1 and Carcinoma
 Nervous System Diseases Antibodies  >8 publications with sDLL1 and Nervous System Diseases
 Abnormalities, Multiple Antibodies  >5 publications with sDLL1 and Abnormalities, Multiple
 Necrosis Antibodies  >5 publications with sDLL1 and Necrosis
 Lung Diseases Antibodies  >5 publications with sDLL1 and Lung Diseases
 Skin Diseases Antibodies  >4 publications with sDLL1 and Skin Diseases

Organs/Tissues associated with sDLL1 active protein

 Organ/Tissue Name  Pubmed Publications
 Embryonic Tissue Antibodies  >41 publications with sDLL1 and Embryonic Tissue
 Brain Antibodies  >39 publications with sDLL1 and Brain
 Lung Antibodies  >16 publications with sDLL1 and Lung
 Intestine Antibodies  >12 publications with sDLL1 and Intestine
 Kidney Antibodies  >8 publications with sDLL1 and Kidney
 Eye Antibodies  >7 publications with sDLL1 and Eye
 Skin Antibodies  >6 publications with sDLL1 and Skin
 Ear Antibodies  >5 publications with sDLL1 and Ear
 Placenta Antibodies  >4 publications with sDLL1 and Placenta
 Lymph Node Antibodies  >4 publications with sDLL1 and Lymph Node
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