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TNIK Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS5400833

Overview: Serine/threonine kinase that acts as an essential activator of the Wnt signaling pathway. Recruited to promoters of Wnt target genes and required to activate their expression. May act by phosphorylating TCF4/TCF7L2. Appears to act upstream of the… More details

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Testing Data View PDF
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Technical Datasheet View PDF
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Product Overview

Online Datasheet in PDF
Product Name
TNIK, Polyclonal Antibody
Full Product Name
TNIK Antibody FITC
Product Gene Name
anti-TNIK antibody
Product Synonym Names
FITC-Conjugated TRAF2 and NCK-interacting protein kinase Antibody; EC 2.7.11.1 antibody; KIAA0551 antibody; Tnik antibody; TNIK_HUMAN antibody; Traf2 and NCK interacting kinase antibody
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human, Mouse, Rat
Purity/Purification
Immobilized antigen affinity chromatography
Concentration
0.5-1.5 ug/ul in antibody stabilization buffer (lot specific)
Preparation and Storage
Store at -20 degree C for long term storage.
Molecular Weight
144,251 Da
3D Structure
ModBase 3D Structure for Q9UKE5
Immunogen
Sythetic peptide taken within amino acid region 1250-1300 on human TRAF2 and NCK-interacting protein kinase protein.
Conjugation
FITC
Molecular Function
ATP binding; MAP kinase kinase kinase kinase activity; protein kinase activity; protein serine/threonine kinase activity
Subcellular Location
Nucleus; Cytoskeleton; Endosome
Applications Tested/Suitable for anti-TNIK antibody
ELISA (EIA), Immunoprecipitation (IP), Western Blot (WB)
Application Notes for anti-TNIK antibody
ELISA: 1:50,000
IP: 1:200
WB: 1:2,500-1:5,000

Other Notes

Small volumes of anti-TNIK antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for TNIK purchase

MBS5400833 is an antibody targeting TNIK. Also known as TNIK Antibody FITC. Reactive in Human, Mouse, Rat. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for TNIK. It may not necessarily be applicable to this product.

NCBI GI #
239735580
NCBI GeneID
23043
NCBI Accession #
NP_001155032.1
UniProt Primary Accession #
Q9UKE5
UniProt Secondary Accession #
O60298; Q8WUY7; Q9UKD8; Q9UKD9; Q9UKE0; Q9UKE1; Q9UKE2; Q9UKE3; A7E2A3; A8K4U1; D3DNQ6
UniProt Related Accession #
Q9UKE5
GenBank Nucleotide #
NM_001161560.2
NCBI Official Full Name
TRAF2 and NCK-interacting protein kinase isoform 2
NCBI Official Synonym Full Names
TRAF2 and NCK interacting kinase
NCBI Official Symbol
TNIK
NCBI Official Synonym Symbols
MRT54
UniProt Protein Name
TRAF2 and NCK-interacting protein kinase
Protein Family
TRAF2 and NCK-interacting protein kinase
UniProt Gene Name
TNIK
UniProt Synonym Gene Names
KIAA0551
NCBI Protein Information
TRAF2 and NCK-interacting protein kinase

NCBI Summary for TNIK

Wnt signaling plays important roles in carcinogenesis and embryonic development. The protein encoded by this gene is a serine/threonine kinase that functions as an activator of the Wnt signaling pathway. Mutations in this gene are associated with an autosomal recessive form of cognitive disability. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2017]
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UniProt Comments for TNIK

Serine/threonine kinase that acts as an essential activator of the Wnt signaling pathway. Recruited to promoters of Wnt target genes and required to activate their expression. May act by phosphorylating TCF4/TCF7L2. Appears to act upstream of the JUN N-terminal pathway. May play a role in the response to environmental stress. Part of a signaling complex composed of NEDD4, RAP2A and TNIK which regulates neuronal dendrite extension and arborization during development. More generally, it may play a role in cytoskeletal rearrangements and regulate cell spreading. Phosphorylates SMAD1 on Thr-322.
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Research Articles on TNIK

1. Results indicate that Traf2- and Nck-interacting kinase (TNIK) is involved in the interleukin-6-dependent proliferation of multiple myeloma cells.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Pathways associated with anti-TNIK antibody

 Products by Pathway  Pathway Diagram
 Cellular Senescence Pathway antibodies  Cellular Senescence Pathway Diagram
 Cellular Responses To Stress Pathway antibodies  Cellular Responses To Stress Pathway Diagram
 Oxidative Stress Induced Senescence Pathway antibodies  Oxidative Stress Induced Senescence Pathway Diagram
 Regulation Of Wnt-mediated Beta Catenin Signaling And Target Gene Transcription Pathway antibodies  Regulation Of Wnt-mediated Beta Catenin Signaling And Target Gene Transcription Pathway Diagram
 TNF Receptor Signaling Pathway antibodies  TNF Receptor Signaling Pathway Diagram

Diseases associated with anti-TNIK antibody

 Disease Name  Pubmed Publications
 Necrosis Antibodies  >4 publications with TNIK and Necrosis
 Cognition Disorders Antibodies  >2 publications with TNIK and Cognition Disorders
 Breast Neoplasms Antibodies  >2 publications with TNIK and Breast Neoplasms
 Congenital Abnormalities Antibodies  >2 publications with TNIK and Congenital Abnormalities
 Disease Models, Animal Antibodies  >2 publications with TNIK and Disease Models, Animal
 Skin Diseases Antibodies  >2 publications with TNIK and Skin Diseases
 Cell Transformation, Neoplastic Antibodies  >1 publications with TNIK and Cell Transformation, Neoplastic
 Carcinoma, Hepatocellular Antibodies  >1 publications with TNIK and Carcinoma, Hepatocellular
 Nervous System Diseases Antibodies  >1 publications with TNIK and Nervous System Diseases
 Adenocarcinoma Antibodies  >1 publications with TNIK and Adenocarcinoma

Organs/Tissues associated with anti-TNIK antibody

 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >14 publications with TNIK and Brain
 Bone Antibodies  >3 publications with TNIK and Bone
 Blood Antibodies  >2 publications with TNIK and Blood
 Intestine Antibodies  >2 publications with TNIK and Intestine
 Lymph Node Antibodies  >1 publications with TNIK and Lymph Node
 Vascular Antibodies  >1 publications with TNIK and Vascular
 Embryonic Tissue Antibodies  >1 publications with TNIK and Embryonic Tissue
 Lung Antibodies  >1 publications with TNIK and Lung
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