CCR2 Antibody – Rabbit Polyclonal

CCR2: a seven transmembrane protein closely related to CCR1. Receptor for the MCP-1, MCP-3 and MCP-4 chemokines. Expressed at high levels in primary neutrophils and primary monocytes, and is further upregulated on neutrophil activation and during monocyte to macrophage differentiation. Transduces a signal by increasing the intracellular calcium ions level. Alternative co receptor with CD4 for HIV-1 infection. Two splice-variant isoforms have been described.

Protein type: Membrane protein, multi-pass; GPCR, family 1; Membrane protein, integral; Receptor, GPCR

Chromosomal Location of Human Ortholog: 3p21.31

Cellular Component: cell soma; cell surface; cytoplasm; cytosol; dendrite; endosome; integral to membrane; integral to plasma membrane; perikaryon; perinuclear region of cytoplasm; plasma membrane

Molecular Function: C-C chemokine receptor activity; CCR2 chemokine receptor binding; chemokine receptor activity; protein homodimerization activity; protein kinase binding

Biological Process: aging; blood vessel remodeling; cellular calcium ion homeostasis; cellular defense response; cellular homeostasis; chemotaxis; cytokine and chemokine mediated signaling pathway; defense response to bacterium; dendritic cell chemotaxis; elevation of cytosolic calcium ion concentration; fat cell differentiation; forebrain development; G-protein coupled receptor protein signaling pathway; immune response; inflammatory response; inflammatory response to antigenic stimulus; JAK-STAT cascade; negative regulation of adenylate cyclase activity; negative regulation of angiogenesis; negative regulation of axon extension; negative regulation of cell migration; negative regulation of eosinophil degranulation; negative regulation of T-helper 2 type immune response; positive regulation of alpha-beta T cell proliferation; positive regulation of apoptosis by virus; positive regulation of fever; positive regulation of inflammatory response; positive regulation of interferon-gamma production; positive regulation of interleukin-1 beta secretion; positive regulation of interleukin-2 production; positive regulation of interleukin-6 production; positive regulation of neuron differentiation; positive regulation of T cell activation; positive regulation of T-helper 1 type immune response; positive regulation of tumor necrosis factor biosynthetic process; response to ionizing radiation; response to lipopolysaccharide; response to wounding