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5HT1B Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS540154

Affinity Purified 5 Hydroxytryptamine 1B receptor AntibodyG-protein coupled receptor for serotonin (5-hydroxytryptamine). Functions as a receptor for various drugs which cause conformational change upon ligand binding that triggers signaling via guanine… More details

$480 / 0.1 mg +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
5HT1B, Polyclonal Antibody
Full Product Name
5HT1B Receptor Antibody Affinity Purified
Product Gene Name
anti-5HT1B antibody
Product Synonym Names
HTR1DB; S12; Serotonin 1D beta receptor antibody
Clonality
Polyclonal
Host
Rabbit
Form/Format
Affinity Purified Immunoglobulins
Concentration
One hundred micrograms (100ug) antibody in 180-200ul of antibody stabilization buffer. (lot specific)
Preparation and Storage
-20 degree C for long term storage
Antibody/Peptide Pairs
5HT1B peptide (MBS542301) is used for blocking the activity of 5HT1B antibody (MBS540154)
Matching Pairs
Antibody: 5HT1B (MBS540154)
Positive Control: 5HT1B (MBS542495)
3D Structure
ModBase 3D Structure for P28334
Immunogen
Synthetic peptide taken within amino acid region 160-260 on rat 5HT1B
Species Cross Reactivity
Human, Mouse, Rat

Product Categories/Family for anti-5HT1B antibody

Primary Antibodies; Neuroscience; Neurotransmission; 5HT1B Antibody
Applications Tested/Suitable for anti-5HT1B antibody
ELISA (EIA), Western Blot (WB), Immunoprecipitation (IP)
Application Notes for anti-5HT1B antibody
Dot Blot: 1:50,000
ELISA: 1:50,000
Immunoprecipitation: 1:200
Western Blot: 1:2,500-1:5,000

Other Notes

Small volumes of anti-5HT1B antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for 5HT1B purchase

MBS540154 is an antibody targeting 5HT1B. Also known as 5HT1B Receptor Antibody Affinity Purified. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for 5HT1B. It may not necessarily be applicable to this product.

NCBI GI #
112814
NCBI GeneID
15551
NCBI Accession #
P28334.1
UniProt Primary Accession #
P28334
UniProt Related Accession #
P28334
NCBI Official Full Name
5-hydroxytryptamine receptor 1B
NCBI Official Synonym Full Names
5-hydroxytryptamine (serotonin) receptor 1B
NCBI Official Symbol
Htr1b
UniProt Protein Name
5-hydroxytryptamine receptor 1B
UniProt Synonym Protein Names
Serotonin receptor 1B
UniProt Gene Name
Htr1b
UniProt Synonym Gene Names
5ht1b; 5-HT-1B; 5-HT1B
UniProt Entry Name
5HT1B_MOUSE
NCBI Protein Information
5-hydroxytryptamine receptor 1B

UniProt Comments for 5HT1B

5-HT(1B): This is one of the several different receptors for 5- hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. The activity of this receptor is mediated by G proteins that inhibit adenylate cyclase activity. Belongs to the G-protein coupled receptor 1 family.

Protein type: Membrane protein, integral; Receptor, GPCR; GPCR, family 1; Membrane protein, multi-pass

Cellular Component: cytoplasm; integral to membrane; integral to plasma membrane; membrane; plasma membrane

Molecular Function: drug binding; G-protein coupled receptor activity; serotonin binding; serotonin receptor activity; signal transducer activity

Biological Process: behavior; bone remodeling; drinking behavior; feeding behavior; G-protein coupled receptor internalization; G-protein coupled receptor protein signaling pathway; negative regulation of cAMP biosynthetic process; negative regulation of serotonin secretion; negative regulation of synaptic transmission, GABAergic; negative regulation of synaptic transmission, glutamatergic; protein kinase C activation; regulation of behavior; regulation of dopamine secretion; response to cocaine; response to drug; response to ethanol; response to toxin; serotonin receptor, adenylate cyclase inhibiting pathway; signal transduction; synaptic transmission; vasoconstriction
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Research Articles on 5HT1B

1. 5-HT1B Knockout and pharmacologic 5-HT1B antagonism both attenuated locomotor hyperactivity in dopamine transporter Knockout mice.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-5HT1B antibody

 Reference Product  PubMed Publications
 Htr1a antibody  >40 publications with 5HT1B and Htr1a
 Npy antibody  >3 publications with 5HT1B and Npy
 Cnr1 antibody  >2 publications with 5HT1B and Cnr1
 Grm7 antibody  >2 publications with 5HT1B and Grm7
 Grm8 antibody  >1 publications with 5HT1B and Grm8
 Pomc antibody  >1 publications with 5HT1B and Pomc

Pathways associated with anti-5HT1B antibody

 Products by Pathway  Pathway Diagram
 Amine Ligand-binding Receptors Pathway antibodies  Amine Ligand-binding Receptors Pathway Diagram
 Class A/1 (Rhodopsin-like Receptors) Pathway antibodies  Class A/1 (Rhodopsin-like Receptors) Pathway Diagram
 G Alpha (i) Signalling Events Pathway antibodies  G Alpha (i) Signalling Events Pathway Diagram
 GPCR Downstream Signaling Pathway antibodies  GPCR Downstream Signaling Pathway Diagram
 GPCR Ligand Binding Pathway antibodies  GPCR Ligand Binding Pathway Diagram
 GPCRs, Class A Rhodopsin-like Pathway antibodies  GPCRs, Class A Rhodopsin-like Pathway Diagram
 Monoamine GPCRs Pathway antibodies  Monoamine GPCRs Pathway Diagram
 Neuroactive Ligand-receptor Interaction Pathway antibodies  Neuroactive Ligand-receptor Interaction Pathway Diagram
 Neuroactive Ligand-receptor Interaction Pathway antibodies  Neuroactive Ligand-receptor Interaction Pathway Diagram
 Non-odorant GPCRs Pathway antibodies  Non-odorant GPCRs Pathway Diagram

Diseases associated with anti-5HT1B antibody

 Disease Name  Pubmed Publications
 Mental Disorders Antibodies  >100 publications with 5HT1B and Mental Disorders
 Nervous System Diseases Antibodies  >51 publications with 5HT1B and Nervous System Diseases
 Brain Diseases Antibodies  >42 publications with 5HT1B and Brain Diseases
 Migraine Disorders Antibodies  >40 publications with 5HT1B and Migraine Disorders
 Headache Antibodies  >25 publications with 5HT1B and Headache
 Depressive Disorder Antibodies  >19 publications with 5HT1B and Depressive Disorder
 Pain Antibodies  >18 publications with 5HT1B and Pain
 Anxiety Disorders Antibodies  >17 publications with 5HT1B and Anxiety Disorders
 Inflammation Antibodies  >10 publications with 5HT1B and Inflammation
 Hypothermia Antibodies  >8 publications with 5HT1B and Hypothermia
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