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CXCR5 Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS540170

Affinity Purified Chemokine (C-X-C motif) receptor 5 AntibodyCytokine receptor that binds to B-lymphocyte chemoattractant (BLC). Involved in B-cell migration into B-cell follicles of spleen and Peyer patches but not into those of mesenteric or peripheral… More details

$480 / 0.1 mg +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
CXCR5, Polyclonal Antibody
Full Product Name
CXCR5 Antibody Affinity Purified
Product Gene Name
anti-CXCR5 antibody
Product Synonym Names
BLR 1; Burkitt lymphoma receptor 1, GTP binding protein (chemokine (C-X-C motif) receptor 5); C X C chemokine receptor type 5; CD 185; Chemokine receptor 5; CXC chemokine receptor type 5; CXCR-5; MDR 15; MGC117347; Monocyte-derived receptor 15 antibody
Clonality
Polyclonal
Host
Rabbit
Species Reactivity
Human
Form/Format
Affinity Purified
Concentration
0.50-1.20 ug/ul in antibody stabilization buffer (lot specific)
Preparation and Storage
-20 degree C for long term storage
Matching Pairs
Antibody: CXCR5 (MBS540170)
Positive Control: CXCR5 (MBS542667)
Antibody/Peptide Pairs
CXCR5 peptide (MBS543393) is used for blocking the activity of CXCR5 antibody (MBS540170)
Molecular Weight
36,676 Da
OMIM
601613
3D Structure
ModBase 3D Structure for P32302
Immunogen
Synthetic peptide taken within amino acid region 320-370 on human Chemokine (C-X-C motif) receptor 5 protein.
Expression
Expression in mature B-cells and Burkitt lymphoma cells
Molecular Function
B-cell activation.
Structure
Belongs to the G-protein coupled receptor 1 family
Subcellular Location
Integral component of Plasma membrane; External side of Plasma membrane

Product Categories/Family for anti-CXCR5 antibody

Primary Antibodies; Immunology; Innate Immunity; Chemokines; CXCR5 Antibody
Applications Tested/Suitable for anti-CXCR5 antibody
ELISA (EIA), Immunoprecipitation (IP), Western Blot (WB)
Application Notes for anti-CXCR5 antibody
Dot Blot: 1:10,000
ELISA: 1:10,000
Immunoprecipitation: 1:200
Western Blot: 1:500

Other Notes

Small volumes of anti-CXCR5 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for CXCR5 purchase

MBS540170 is an antibody targeting CXCR5. Also known as CXCR5 Antibody Affinity Purified. Reactive in Human. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for CXCR5. It may not necessarily be applicable to this product.

NCBI GI #
82571482
NCBI GeneID
643
NCBI Accession #
AAI10353.1
UniProt Primary Accession #
P32302
UniProt Secondary Accession #
Q14811
UniProt Related Accession #
P32302
NCBI Official Full Name
Chemokine (C-X-C motif) receptor 5
NCBI Official Synonym Full Names
C-X-C motif chemokine receptor 5
NCBI Official Symbol
CXCR5
NCBI Official Synonym Symbols
BLR1; CD185; MDR15
UniProt Protein Name
C-X-C chemokine receptor type 5
UniProt Synonym Protein Names
Burkitt lymphoma receptor 1; Monocyte-derived receptor 15; MDR-15; CD_antigen: CD185
Protein Family
C-X-C chemokine receptor
UniProt Gene Name
CXCR5
UniProt Synonym Gene Names
BLR1; MDR15; CXC-R5; CXCR-5; MDR-15
UniProt Entry Name
CXCR5_HUMAN
NCBI Protein Information
C-X-C chemokine receptor type 5

NCBI Summary for CXCR5

This gene encodes a multi-pass membrane protein that belongs to the CXC chemokine receptor family. It is expressed in mature B-cells and Burkitt's lymphoma. This cytokine receptor binds to B-lymphocyte chemoattractant (BLC), and is involved in B-cell migration into B-cell follicles of spleen and Peyer patches. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Aug 2011]
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UniProt Comments for CXCR5

CXCR5: Cytokine receptor that binds to B-lymphocyte chemoattractant (BLC). Involved in B-cell migration into B-cell follicles of spleen and Peyer patches but not into those of mesenteric or peripheral lymph nodes. May have a regulatory function in Burkitt lymphoma (BL) lymphomagenesis and/or B-cell differentiation. Belongs to the G-protein coupled receptor 1 family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: GPCR, family 1; Receptor, GPCR; Membrane protein, integral; Membrane protein, multi-pass

Chromosomal Location of Human Ortholog: 11q23.3

Cellular Component: external side of plasma membrane; integral to plasma membrane; plasma membrane

Molecular Function: C-X-C chemokine receptor activity; G-protein coupled receptor activity; protein binding

Biological Process: B cell activation; cell motility; chemotaxis; G-protein coupled receptor protein signaling pathway; immune response; lymph node development; positive regulation of cytokinesis
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Research Articles on CXCR5

1. study showed that induction of circulating CXCR5+CD4+ Tfh-like subsets can be detected following immunization with HPV vaccines, and potentially be useful as a marker of immunogenicity of vaccines

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-CXCR5 antibody

 Reference Product  PubMed Publications
 CXCL13 antibody  >229 publications with CXCR5 and CXCL13
 CXCR4 antibody  >157 publications with CXCR5 and CXCR4
 CXCL12 antibody  >73 publications with CXCR5 and CXCL12
 CCL19 antibody  >35 publications with CXCR5 and CCL19
 CCL21 antibody  >31 publications with CXCR5 and CCL21
 CCL5 antibody  >16 publications with CXCR5 and CCL5
 CCL4 antibody  >6 publications with CXCR5 and CCL4
 CCL28 antibody  >2 publications with CXCR5 and CCL28
 CCL27 antibody  >1 publications with CXCR5 and CCL27

Pathways associated with anti-CXCR5 antibody

 Products by Pathway  Pathway Diagram
 Chemokine Receptors Bind Chemokines Pathway antibodies  Chemokine Receptors Bind Chemokines Pathway Diagram
 Chemokine Signaling Pathway antibodies  Chemokine Signaling Pathway Diagram
 Chemokine Signaling Pathway antibodies  Chemokine Signaling Pathway Diagram
 Class A/1 (Rhodopsin-like Receptors) Pathway antibodies  Class A/1 (Rhodopsin-like Receptors) Pathway Diagram
 Cytokine-cytokine Receptor Interaction Pathway antibodies  Cytokine-cytokine Receptor Interaction Pathway Diagram
 Cytokine-cytokine Receptor Interaction Pathway antibodies  Cytokine-cytokine Receptor Interaction Pathway Diagram
 G Alpha (i) Signalling Events Pathway antibodies  G Alpha (i) Signalling Events Pathway Diagram
 GPCR Downstream Signaling Pathway antibodies  GPCR Downstream Signaling Pathway Diagram
 GPCR Ligand Binding Pathway antibodies  GPCR Ligand Binding Pathway Diagram
 GPCRs, Class A Rhodopsin-like Pathway antibodies  GPCRs, Class A Rhodopsin-like Pathway Diagram

Diseases associated with anti-CXCR5 antibody

 Disease Name  Pubmed Publications
 Immune System Diseases Antibodies  >258 publications with CXCR5 and Immune System Diseases
 Inflammation Antibodies  >113 publications with CXCR5 and Inflammation
 Necrosis Antibodies  >47 publications with CXCR5 and Necrosis
 Disease Models, Animal Antibodies  >43 publications with CXCR5 and Disease Models, Animal
 Immunologic Deficiency Syndromes Antibodies  >41 publications with CXCR5 and Immunologic Deficiency Syndromes
 Liver Diseases Antibodies  >24 publications with CXCR5 and Liver Diseases
 Lung Diseases Antibodies  >24 publications with CXCR5 and Lung Diseases
 Kidney Diseases Antibodies  >22 publications with CXCR5 and Kidney Diseases
 Carcinoma Antibodies  >22 publications with CXCR5 and Carcinoma
 Breast Neoplasms Antibodies  >9 publications with CXCR5 and Breast Neoplasms

Organs/Tissues associated with anti-CXCR5 antibody

 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >619 publications with CXCR5 and Blood
 Lymph Node Antibodies  >253 publications with CXCR5 and Lymph Node
 Lymph Antibodies  >148 publications with CXCR5 and Lymph
 Spleen Antibodies  >87 publications with CXCR5 and Spleen
 Pharynx Antibodies  >36 publications with CXCR5 and Pharynx
 Lung Antibodies  >31 publications with CXCR5 and Lung
 Thymus Antibodies  >27 publications with CXCR5 and Thymus
 Skin Antibodies  >24 publications with CXCR5 and Skin
 Intestine Antibodies  >18 publications with CXCR5 and Intestine
 Prostate Antibodies  >12 publications with CXCR5 and Prostate
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