CD36 Antibody – Rabbit Polyclonal

CD36: Seems to have numerous potential physiological functions. Binds to collagen, thrombospondin, anionic phospholipids and oxidized LDL. May function as a cell adhesion molecule. Directly mediates cytoadherence of Plasmodium falciparum parasitized erythrocytes. Binds long chain fatty acids and may function in the transport and/or as a regulator of fatty acid transport. Receptor for thombospondins, THBS1 AND THBS2, mediating their antiangiogenic effects. Defects in CD36 are the cause of platelet glycoprotein IV deficiency (PG4D)[MIM:608404]; also known as CD36 deficiency. Platelet glycoprotein IV deficiency can be divided into 2 subgroups. The type I phenotype is characterized by platelets and monocytes/macrophages exhibiting complete CD36 deficiency. The type II phenotype lacks the surface expression of CD36 in platelets, but expression in monocytes/macrophages is near normal. Genetic variations in CD36 are associated with susceptibility to coronary heart disease type 7 (CHDS7). Belongs to the CD36 family.

Protein type: Cell adhesion; Membrane protein, integral; Membrane protein, multi-pass

Chromosomal Location of Human Ortholog: 7q11.2

Cellular Component: apical plasma membrane; brush border membrane; cell surface; cytosol; external side of plasma membrane; extracellular space; Golgi apparatus; integral to plasma membrane; lipid raft; membrane; phagocytic vesicle; plasma membrane; platelet alpha granule membrane

Molecular Function: high-density lipoprotein binding; lipid binding; low-density lipoprotein binding; low-density lipoprotein receptor activity; protein binding; transforming growth factor beta binding

Biological Process: antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent; apoptotic cell clearance; blood coagulation; cell adhesion; cell surface receptor linked signal transduction; cGMP-mediated signaling; cholesterol absorption; cholesterol transport; defense response to Gram-positive bacterium; elevation of cytosolic calcium ion concentration; immune response; interleukin-1 beta secretion; intestinal absorption; lipid metabolic process; lipoprotein transport; low density lipoprotein mediated signaling; MyD88-dependent toll-like receptor signaling pathway; negative regulation of transcription factor import into nucleus; negative regulation of transcription from RNA polymerase II promoter; nitric oxide mediated signal transduction; phagocytosis, recognition; platelet degranulation; positive regulation of blood coagulation; positive regulation of cell-matrix adhesion; positive regulation of I-kappaB kinase/NF-kappaB cascade; positive regulation of interleukin-12 production; positive regulation of interleukin-6 production; positive regulation of peptidyl-tyrosine phosphorylation; positive regulation of phagocytosis, engulfment; positive regulation of tumor necrosis factor production; receptor internalization; receptor-mediated endocytosis; response to lipid; sensory perception of taste; sequestering of lipid; triacylglycerol transport

Disease: Coronary Heart Disease, Susceptibility To, 7; Malaria, Susceptibility To; Platelet Glycoprotein Iv Deficiency