• Call +1.858.633.0165 or Fax +1.858.633.0166 or Contact Us

5HT1A Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS540293

Affinity Purified 5 Hydroxytryptamine 1A receptor AntibodyG-protein coupled receptor for serotonin (5-hydroxytryptamine). Functions as a receptor for various drugs which cause conformational change upon ligand binding that triggers signaling via guanine… More details

$480 / 0.1 mg +1 FREE 8GB USB
Product Documentation
PDF
Sample Manual Insert View PDF
PDF
Testing Data View PDF
PDF
Certificate of Analysis (COA) View PDF
PDF
QC Report View PDF
PDF
Material Safety Data Sheet View PDF
PDF
Technical Datasheet View PDF
PDF
Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
5HT1A, Polyclonal Antibody
Full Product Name
5HT1A Receptor Antibody
Product Gene Name
anti-5HT1A antibody
Product Synonym Names
ADRBRL1; G 21; Gpcr18; Guanine nucleotide binding regulatory protein-coupled receptor; HTR1A; PFMCD antibody
Clonality
Polyclonal
Host
Rabbit
Species Reactivity
Human, Mouse, Rat
Form/Format
Affinity Purified
Concentration
0.5-1.5 ug/ul in antibody stabilization buffer (lot specific)
Preparation and Storage
-20 degree C for long term storage
Antibody/Peptide Pairs
5HT1A peptide (MBS542300) is used for blocking the activity of 5HT1A antibody (MBS540293)
Matching Pairs
Antibody: 5HT1A (MBS540293)
Positive Control: 5HT1A (MBS542494)
Molecular Weight
46,429 Da
3D Structure
ModBase 3D Structure for P19327
Immunogen
Synthetic peptide corresponding to amino acids within region 200-250 on rat 5-hydroxytrptamine receptor 1A protein.
Expression
Lymph nodes, thymus, spleen, activated T-cells
Molecular Function
serotonin receptor activity
Structure
Heterodimer
Subcellular Location
Cell membrane; Multi-pass protein

Product Categories/Family for anti-5HT1A antibody

Primary Antibodies; Neuroscience; Neurotransmission; 5HT1A Antibody
Applications Tested/Suitable for anti-5HT1A antibody
ELISA (EIA), Immunoprecipitation (IP), Western Blot (WB)
Application Notes for anti-5HT1A antibody
Dot Blot: 1:50,000
ELISA: 1:50,000
Immunoprecipitation: 1:200
Western Blot: 1:2,500-1:5,000

Western Blot (WB) of anti-5HT1A antibody

Rabbit Anti-5HT1A Polyclonal Antibody – Cat# MBS540293

Other Notes

Small volumes of anti-5HT1A antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for 5HT1A purchase

MBS540293 is an antibody targeting 5HT1A. Also known as 5HT1A Receptor Antibody. Reactive in Human, Mouse, Rat. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for 5HT1A. It may not necessarily be applicable to this product.

NCBI GI #
6981054
NCBI GeneID
24473
NCBI Accession #
NP_036717
UniProt Primary Accession #
P19327
UniProt Related Accession #
P19327
GenBank Nucleotide #
NM_012585.1
NCBI Official Full Name
5-hydroxytryptamine receptor 1A
NCBI Official Synonym Full Names
5-hydroxytryptamine receptor 1A
NCBI Official Symbol
Htr1a
NCBI Official Synonym Symbols
5HT1A; RAT5HT1A
UniProt Protein Name
5-hydroxytryptamine receptor 1A
UniProt Synonym Protein Names
Serotonin receptor 1A
UniProt Gene Name
Htr1a
UniProt Synonym Gene Names
5ht1a; 5-HT-1A; 5-HT1A
UniProt Entry Name
5HT1A_RAT
NCBI Protein Information
5-hydroxytryptamine receptor 1A

NCBI Summary for 5HT1A

regulates AMPA receptor channels in the prefrontal cortex; regulation is mediated via inhibition of Ca2+/calmodulin-dependent kinase II [RGD, Feb 2006]

UniProt Comments for 5HT1A

5-HT(1A): This is one of the several different receptors for 5- hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. The activity of this receptor is mediated by G proteins that inhibit adenylate cyclase activity. Belongs to the G-protein coupled receptor 1 family. 5- hydroxytryptamine receptor subfamily. HTR1A sub-subfamily.

Protein type: Receptor, GPCR; Membrane protein, multi-pass; GPCR, family 1; Membrane protein, integral

Cellular Component: axon hillock; cell soma; integral to plasma membrane; membrane

Molecular Function: drug binding; G-protein alpha-subunit binding; protein binding; serotonin binding; serotonin receptor activity

Biological Process: behavioral fear response; cell proliferation; G-protein coupled receptor protein signaling pathway; positive regulation of microtubule depolymerization; regulation of behavior; regulation of dopamine metabolic process; regulation of hormone secretion; regulation of serotonin secretion; serotonin metabolic process; serotonin receptor signaling pathway; serotonin receptor, adenylate cyclase inhibiting pathway; vasoconstriction
Show more

Research Articles on 5HT1A

1. daily repeated brief separation from pups results in increased maternal rat brain ERalpha, ERbeta, and oxytocin receptor, as well as decreased 5-HT1ARs in the dam's brain

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Pathways associated with anti-5HT1A antibody

 Products by Pathway  Pathway Diagram
 Amine Ligand-binding Receptors Pathway antibodies  Amine Ligand-binding Receptors Pathway Diagram
 Class A/1 (Rhodopsin-like Receptors) Pathway antibodies  Class A/1 (Rhodopsin-like Receptors) Pathway Diagram
 G Alpha (i) Signalling Events Pathway antibodies  G Alpha (i) Signalling Events Pathway Diagram
 GPCR Downstream Signaling Pathway antibodies  GPCR Downstream Signaling Pathway Diagram
 GPCR Ligand Binding Pathway antibodies  GPCR Ligand Binding Pathway Diagram
 GPCRs, Class A Rhodopsin-like Pathway antibodies  GPCRs, Class A Rhodopsin-like Pathway Diagram
 Monoamine GPCRs Pathway antibodies  Monoamine GPCRs Pathway Diagram
 Neuroactive Ligand-receptor Interaction Pathway antibodies  Neuroactive Ligand-receptor Interaction Pathway Diagram
 Neuroactive Ligand-receptor Interaction Pathway antibodies  Neuroactive Ligand-receptor Interaction Pathway Diagram
 Serotonergic Synapse Pathway antibodies  Serotonergic Synapse Pathway Diagram

Diseases associated with anti-5HT1A antibody

 Disease Name  Pubmed Publications
 Mental Disorders Antibodies  >101 publications with 5HT1A and Mental Disorders
 Mood Disorders Antibodies  >56 publications with 5HT1A and Mood Disorders
 Depressive Disorder Antibodies  >55 publications with 5HT1A and Depressive Disorder
 Depressive Disorder, Major Antibodies  >47 publications with 5HT1A and Depressive Disorder, Major
 Anxiety Disorders Antibodies  >30 publications with 5HT1A and Anxiety Disorders
 Bipolar Disorder Antibodies  >12 publications with 5HT1A and Bipolar Disorder
 Panic Disorder Antibodies  >10 publications with 5HT1A and Panic Disorder
 Personality Disorders Antibodies  >9 publications with 5HT1A and Personality Disorders
 Pain Antibodies  >6 publications with 5HT1A and Pain
 Cognition Disorders Antibodies  >3 publications with 5HT1A and Cognition Disorders

Organs/Tissues associated with anti-5HT1A antibody

 Organ/Tissue Name  Pubmed Publications
 Mixed Antibodies  >5 publications with 5HT1A and Mixed
Request a Quote

Please fill out the form below and our representative will get back to you shortly.

MBS000000
Contact Us

Please fill out the form below and our representative will get back to you shortly.

MBS000000