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Chimaerin Beta 2 (CHN2) Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS540311

Affinity Purified Beta-chimaerin AntibodyGTPase-activating protein for p21-rac. May play role in progression from low-grade to high-grade tumors. More details

$480 / 0.1 mg +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
Chimaerin beta 2 (CHN2), Polyclonal Antibody
Full Product Name
Chimaerin beta 2 Antibody
Product Gene Name
Product Synonym Names
ARHGAP3; BCH; CHN2; MGC138360; Rho GTPase activating protein 3; RHOGAP3 antibody
Clonality
Polyclonal
Host
Rabbit
Species Reactivity
Human, Mouse, Rat
Form/Format
Affinity Purified
Concentration
0.68-0.71 ug/ul in antibody stabilization buffer (lot specific)
Preparation and Storage
-20 degree C for long term storage
Molecular Weight
62,441 Da
OMIM
602857
3D Structure
ModBase 3D Structure for P52757
Immunogen
Synthetic peptide taken within amino acid region 150-180 on beta 2-chimaerin protein.
Expression
Brain, pancreas, heart, placenta. Weakly expressed in kidney and liver.
Molecular Function
Metal binding; Zinc
Structure
Contains 1 phorbol-ester/DAG-type zinc finger; 1 Rho-GAP domain; 1 SH2 domain.
Subcellular Location
Membrane
Applications Tested/Suitable for anti-CHN2 antibody
ELISA (EIA), Immunohistochemistry (IHC), Immunoprecipitation (IP), Western Blot (WB)
Application Notes for anti-CHN2 antibody
Western Blot: 1:500

Western Blot (WB) of anti-CHN2 antibody

Rabbit Anti-CHN2 Polyclonal Antibody – Cat# MBS540311

Immunohistochemistry (IHC) of anti-CHN2 antibody

Rabbit Anti-CHN2 Polyclonal Antibody, Immunohistochemistry (IHC) – Cat# MBS540311

Other Notes

Small volumes of anti-CHN2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for CHN2 purchase

MBS540311 is an antibody targeting CHN2. Also known as Chimaerin beta 2 Antibody. Reactive in Human, Mouse, Rat. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for CHN2. It may not necessarily be applicable to this product.

NCBI GI #
NCBI GeneID
NCBI Accession #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
GenBank Nucleotide #
NCBI Official Full Name
Beta-chimaerin
NCBI Official Synonym Full Names
chimerin 2
NCBI Official Symbol
CHN2
NCBI Official Synonym Symbols
BCH; CHN2-3; ARHGAP3; RHOGAP3
UniProt Protein Name
Beta-chimaerin
UniProt Synonym Protein Names
Beta-chimerin; Rho GTPase-activating protein 3
Protein Family
UniProt Gene Name
CHN2
UniProt Synonym Gene Names
ARHGAP3; BCH
UniProt Entry Name
CHIO_HUMAN
NCBI Protein Information
beta-chimaerin

NCBI Summary for CHN2

This gene encodes a guanosine triphosphate (GTP)-metabolizing protein that contains a phorbol-ester/diacylglycerol (DAG)-type zinc finger, a Rho-GAP domain, and an SH2 domain. The encoded protein translocates from the cytosol to the Golgi apparatus membrane upon binding by diacylglycerol (DAG). Activity of this protein is important in cell proliferation and migration, and expression changes in this gene have been detected in cancers. A mutation in this gene has also been associated with schizophrenia in men. Alternative transcript splicing and the use of alternative promoters results in multiple transcript variants. [provided by RefSeq, May 2014]
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UniProt Comments for CHN2

ARHGAP3: GTPase-activating protein for p21-rac. Insufficient expression of beta-2 chimaerin is expected to lead to higher Rac activity and could therefore play a role in the progression from low-grade to high-grade tumors. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: GAPs, Rac/Rho; GAPs

Chromosomal Location of Human Ortholog: 7p15.3

Cellular Component: cytoplasm; cytosol; membrane

Molecular Function: GTPase activator activity; metal ion binding; protein binding; SH3/SH2 adaptor activity

Biological Process: positive regulation of GTPase activity; positive regulation of signal transduction; regulation of small GTPase mediated signal transduction
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Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

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