Aquaporin 8 (AQP8) Antibody – Rabbit Polyclonal

Water channel proteins, known as Aquaporins, are transmembrane proteins that mediate osmotic water permeability. AQPs are a family of homologous water channels widely distributed in pla.nts, unicellular organisms, invertebrates, and vertebrates. Aquaporins are selective water/glycerol channels involved in the maintenance of volume homeostasis and ionic/osmotic balance. These water channels also enhance cellular tolerance against rapid freezing, which suggest that they might have some ecological relevance. Early work of Nobel Prize winner Peter Agre first cloned a 269 amino acid Aquaporin protein from red blood cell and kidney libraries that has six transmembrane domains (1). The amino terminal end of the protein was in the membrane and has two repeats that are at 1800 to each other and are responsible for water selectivity.

The selective antibodies were generated against conserved sequences at the C-terminal end of the protein that is unique to rat/mouse Aquaporin 8 protein. The polyclonal antibodies were affinity purified on an immobilized antigen based affinity chromatography. The isolated antibodies were then stabilized in antibody stabilization buffer for long-term storage. Antigenic blocking peptides (MBS452379) and Western blot positive controls in ready to use SDS-sample buffers (MBS542541) are available.

Small volumes of anti-Aqp8 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

MBS540353 is an antibody targeting Aqp8. Also known as Aquaporin 8 Antibody. Reactive in Bovine, Human, Mouse, Rat, Sheep. Host: Rabbit.