TPCN1 Antibody – Rabbit Polyclonal

TPCN1: one of the major voltage-gated Ca(2+) channel (VDCC) across the plasma membrane. Highest expression found in the heart and kidney, and lowest expression found in the spleen. Each of the two internal repeats contains five hydrophobic transmembrane segments (S1, S2, S3, S5, S6) and one positively charged transmembrane segment (S4). S4 segments probably represent the voltage-sensor and are characterized by a series of positively charged amino acids at every third position. Two alternatively spliced human isoforms have been described.

Protein type: Membrane protein, integral; Transporter, ion channel; Transporter; Membrane protein, multi-pass; Channel, calcium

Chromosomal Location of Human Ortholog: 12q24.13

Cellular Component: endosome; endosome membrane; integral to membrane; lysosomal membrane; lysosome; plasma membrane

Molecular Function: identical protein binding; protein binding; voltage-gated calcium channel activity

Biological Process: positive regulation of autophagy; release of sequestered calcium ion into cytosol