Usherin (USH2A) Antibody – Rabbit Polyclonal

Affinity Purified Usherin isoform A Antibody N-epitope
Usher syndrome , an autosomal recessive heterogeneous disorder, is the most common cause of deafness and blindness in adults and effect 3-6% children born with hearing impairment. The affected individuals have sensory neural deficiencies at birth and subsequently develop progressive retinitis pigmentosa (RP). Three forms of Usher loss and vestibular involvement . Type I patlents are profoundly deaf while type II ( most common form of Usher syndrome ) patients are mildly deaf but have normal vestibular responses. (1). Ush2A gene has been mapped on a 1 mega base pair interval between marker D1S474 and AFM144XF2. The Usher 2A gene expresses an extra cellular matrix protein that ressembles unconventional Myosin and do not appear to have any un-conventional functional correlations. The human Usher Syndrome 2A (Ush2A) protein has 1272 amino acid (Approximate MW 153 kDa) with several functional domains (Laminin type EGF like domain; Laminin-Type epidermal growth factor like domain and fibronectin type 3 like domain.) The protein has a single transmembrane domain that anchor the protein to the cell membrane, the rest of the protein stays outside the cell.

The Ush2A protein is approximately 153 kDa (1272 amino acids ) with multiple conserved domains that is mainly expressed in RPEs. The Anti-Usherin selective antibodies were generated against three regions: N-epitope, Mid Region and C-epitope. These epitope are uique to Usherin protein. The polyclonal antibody strongly labels a 186kDa protein in RPE cell extracts. Anti-Ush2A selective antibodies are also available in affinity purified form for confocal, Western blotting and immunocytochemical analyses. Antibodies can be conjugated with fluorescent probes or secondary enzymes for an extra charge. Western blot positive control in ready-to use SDS sample buffer and antigenic blocking peptides are available.

Small volumes of anti-USH2A antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

MBS540441 is an antibody targeting USH2A. Also known as Usherin Antibody Affinity Purified. Reactive in Human, Monkey, Mouse, Rat. Host: Rabbit.